PhenoVue™ lipid stain
The PhenoVue™ lipid stain is a fluorescent dye conjugated lipophilic organic molecule commonly used for localization and quantification of intracellular lipid droplets, and is validated for use in imaging microscopy and high-content screening applications.
Fluorescent dye options include PhenoVue 493 (bright green alternative to BODIPY™ 493/503) and PhenoVue Nile Red (bright yellow).
PhenoVue Nile Red Lipid stain is a lipophilic organic molecule that is almost non-fluorescent in water and polar solvents. In lipid-rich environments, Nile Red exhibits enhanced yellow fluorescence, as well as red fluorescence to a lesser extent.
PhenoVue 493 Lipid stain is a lipophilic fluorescent organic molecule that localizes to polar lipids. It rapidly accumulates in lipid droplets and exhibits enhanced green fluorescence in the presence of neutral lipids like triglycerides and cholesterol esters.
These lipid stains are commonly used for localization and quantification of intracellular lipid droplets which are involved in lipid synthesis, metabolism and transportation as well as protein storage and degradation or viral replication, all of which are related to pathophysiology, including dyslipidemia, obesity, lipodystrophy, diabetes, fatty liver diseases, or atherosclerosis.
