PhenoVue™ mitochondrial stain
The PhenoVue™ mitochondirial stain is a fluorescent dye conjugated molecule that accumulates in healthy mitochondria of live cells, and is validated for use in imaging microscopy and high-content screening applications.
Fluorescent dye options include PhenoVue 551 (bright orange), PhenoVue 578 (bright orange) and PhenoVue 641 (deep red).
PhenoVue™ mitochondrial stain is a cationic molecule. With mitochondrial membrane potential, it accumulates in mitochondria through electrostatic interactions and reacts with thiol moieties forming stable thioether bonds. Therefore PhenoVue mitochondrial stain is well retained after cell fixation.
Fluorescent mitochondrial stains are commonly used for visualizing and quantifying mitochondria whose dysfunctions, including impaired biogenesis, dynamics or trafficking, are a hallmark of some human diseases, such as neurodegenerative disorders.
PhenoVue mitochondrial stain can be used to detect mitochondria in indirect immunofluorescence, immunohistochemistry and flow cytometry, as well as high-content analysis and screening applications.
