Pooled CRISPR screening service with single-cell transcriptome readout. The single cell approach to research and drug discovery.
CRISPR screening followed by single-cell analysis (CRISPRsc) provides critical gene information on how cellular subpopulations will respond to any treatment.
CRISPRsc enables an unbiased examination of critical genes involved in a phenotypic outcome within a heterogenous cell population, such as a tumor or group of cells at different temporal points in a pathway. This supports greater understanding of differences in cellular responses and subpopulation structure.
Single-cell CRISPR screens
Perform high-throughput screens
Generate ultra-rich whole-transcriptome readouts per perturbation
Distinguish cell subpopulation gene responses to perturbation
Use single-cell CRISPR screens to:
Study variation in cellular differentiation pathways
Characterize cell subpopulations
Clearly identify gene interactions and networks
Understand differences in cell responses to a treatment