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CRISPRi: transcriptional gene repression

CRISPR interference

Knock down target gene transcription without cutting DNA
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Advancing drug discovery from research to therapy

Global CRO solutions & services

Maintain your research velocity during COVID-19 by outsourcing your cell line engineering or screening projects with Horizon.
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Cherry-Pick Custom Library tool

Screen your gene list with a custom mini-library

Design and order your own mini-library with the Cherry-Pick Library Plater tool
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Clinically relevant cell models

Cell models

New pricing for Express and Custom engineering services!
Prices start from £7,500 – delivered in as little as 10 weeks
Get an instant online quote
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Functional genomic and cell panel screening services

Screening services

New! Standard CRISPRko screens - delivered in 16 weeks
• 10 predefined human cell lines
• One compound in up to 4 cell lines, or up to 4 compounds per line
Find out more
CHOSOURCE optimized bioproduction platform

CHO cells

A step change in manufacture - from lead to biotherapeutic
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Horizon Discovery
RNAi solutions by Dharmacon

ON-TARGETplus™ siRNA

Premium siRNA reagents by Dharmacon™ - Guaranteed to silence the target gene with unmatched specificity.

Edit-R CRISPR guide RNA

Edit-R™ synthetic CRISPR sgRNA

Guaranteed to edit the target gene, and designed to maximize the effectiveness of functional gene knockout.

Custom RNA synthesis

Custom synthesis

Custom RNA synthesis by Dharmacon™

Latest news

Horizon Discovery Extends Gene Modulation Portfolio with Industry First Synthetic Single Guide RNA and Patent Pending dCas9 Repressor for CRISPR Interference

Maintain research velocity during COVID

Outsource your cell line engineering or screening projects with Horizon's experienced contract research service teams.

 

Check out our new blog

Learn what is "On the Horizon"

 

banner - CRISPR video series

For transgenic animal models and in vivo screening services

Contact Envigo

Poster: CRISPR screening technologies

Are you interested in arrayed, pooled, or dual CRISPR screening?

Working with primary cells?

Find proven tools and resources for successful CRISPR editing and RNAi in primary cell types.

 

Interested in our screening libraries?

View our extensive collections

Why use CRISPR-Cas9 systems?

Explore gene editing applications.

What is Prime Editing?

Read our featured article for more information