RT-qPCR analysis is critical to success in knockdown experiments. Learn about how to rapidly troubleshoot your knockdown experiment from the RT-qPCR results.
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Arrayed siRNA screens are a powerful tool to look at very precise perturbations in cellular pathways.
Cancer is often characterized by dysregulation in cellular pathways and the checkpoints which control cell proliferation, growth, differentiation, and apoptosis. Within the genome there are two types of genes which carefully control cell proliferation and cell death, which are often the driving force behind oncogenesis.
Revvity’s Dharmacon™ CRISPR portfolio expands with validated CRISPR guide RNAs for complex but critical gene targets, as well as DNA cutting controls for screen normalization in sensitive assays.
Colorectal cancer (CRC) is the abnormal cell growth starting in the lining of the large intestine or rectum
Learn about the MLR assay and why it is an essential component of the compound screening pipeline for drug development.
Here we explain the hurdles to setting up a high-throughput ORF screen, and how CRISPRa offers a new solution that can expand the screening toolbox to maximize your window of discovery.
Thinking about doing CRISPR screening for knock out, CRISPR activation or CRISPRi applications? Unsure whether a synthetic arrayed or pooled lentiviral screening library is best for your project? We are here to help.
Did your initial round of RNAi screening produce some hits? How do you determine which hits are true positives?