T-cell receptors (TCRs) are crucial components of T cell immunity, enabling the detection and subsequent elimination of abnormal, cancerous and infected cells. Dysfunctional T cell receptor signaling can lead to various immune deficiency or autoimmune diseases. In cancer treatment the study and modification of T cell receptor signaling is important for CAR-T cell therapy as well as modulation of the tumor microenvironment (TME). Modulating T cell activation can be important to avoid rejection of organ or stem cell transplants by the immune response.
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With the requirement of thorough in vitro assays and high throughput screening technologies to ensure drug safety and efficacy, make sure you're fully ready for when you submit your IND application by assessing immunogenicity with an MLR assay
Learn about how T cell exhaustion poses a significant challenge in immuno-oncology and the way epigenetic mechanisms can help develop strategies for reinvigorating exhausted T cells.
混合リンパ球反応（MLR）アッセイと、このアッセイが低分子医薬またはバイオ医薬品の免疫系における潜在的な影響を評価するための必須のアッセイである理由について学びます。
Dr. Alex MarsonとDr. Nevan Kroganの研究室によって最近発表された、初代ヒト単球における新しい方法論と研究のディスカッション
Can base editing move cancer cell therapy further towards off-the-shelf treatments?
Gisela Jimenez-Duranらによる最近の論文は、Horizon Discoveryによって実施された全ゲノムCRISPRノックアウトスクリーニングが、炎症誘発性マクロファージを調節できる既存の阻害剤をどのように同定したかをわかりやすく示しています。
Demonstration of a repeatable pooled lentiviral sgRNA screen in primary human T cells
Gene editing by CRISPR has led to significant advances in immunotherapy development. Here we offer several tips for successful editing in T cells, including recommendations for cell handling, nucleofection, and analysis.