Cancer is often characterized by dysregulation in cellular pathways and the checkpoints which control cell proliferation, growth, differentiation, and apoptosis. Within the genome there are two types of genes which carefully control cell proliferation and cell death, which are often the driving force behind oncogenesis.
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mTOR (mechanistic Target of Rapamycin)は環境刺激に応答して細胞増殖を制御するシグナル伝達ネットワークの中心であり、細胞および生体の生理学において不可欠な役割を果たしています。
Atlas of Variant Effects Allianceの目標を達成するために、Wellcome Sanger InstituteはRevvityのHAP1 LIG4(-)細胞株を選択しました。
大腸がん(CRC)は、大腸または直腸の粘膜から始まる異常な細胞増殖です。
The Toll-like receptors (TLRs) are a family of evolutionarily ancient Patten Recognition Receptors (PRRs) that rapidly detect microbial infection and stimulate the production of pro-inflammatory and antiviral cytokines and chemokines, as well as initiating significant metabolic shifts within the cell. Acting as cellular sentinels for infectious threats, signalling downstream of TLRs sets the stage for successful development of adaptive immunity 1.
The adherens junction (AJ), with the core cadherin-catenin complex, is an integral system of cell-cell adhesion. The AJ works to anchor the actin cytoskeleton intracellularly to the plasma membrane while simultaneously linking individual cells through extracellular interactions.
Review of publications using HAP1 cells to set up validation assays beyond the typical western blot.
HAP1細胞株を用いた実験を成功させるための5つのヒント
CRISPRテクノロジーによりゲノム編集細胞集団を作製後、クローン細胞株を用いるかプール細胞集団を用いるかを決定する際に考慮すべき最も重要な4つの事項をご説明しています。
HAP1 cell lines are a popular choice to validate a range of research experiments, but if you've never used them before, you want to be sure they are right for you.