3D culturing is a valuable and increasingly popular cell culture technique. This model recapitulates some physiological characteristics of tissues and tumors driven by cell-cell and cell-matrix contacts, circumventing the need for in vivo experiments in some cases.
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mTOR (mechanistic Target of Rapamycin)は環境刺激に応答して細胞増殖を制御するシグナル伝達ネットワークの中心であり、細胞および生体の生理学において不可欠な役割を果たしています。
Atlas of Variant Effects Allianceの目標を達成するために、Wellcome Sanger InstituteはRevvityのHAP1 LIG4(-)細胞株を選択しました。
Read about Celonic's decision to partner with Revvity to leverage the CHOSOURCE™ expression platform for all their antibody and complex molecular development and manufacturing.
大腸がん(CRC)は、大腸または直腸の粘膜から始まる異常な細胞増殖です。
A blog article and application note demonstrating the use of Revvity's Pin-point base editing platform with sensitive cell types
The Toll-like receptors (TLRs) are a family of evolutionarily ancient Patten Recognition Receptors (PRRs) that rapidly detect microbial infection and stimulate the production of pro-inflammatory and antiviral cytokines and chemokines, as well as initiating significant metabolic shifts within the cell. Acting as cellular sentinels for infectious threats, signalling downstream of TLRs sets the stage for successful development of adaptive immunity 1.
The adherens junction (AJ), with the core cadherin-catenin complex, is an integral system of cell-cell adhesion. The AJ works to anchor the actin cytoskeleton intracellularly to the plasma membrane while simultaneously linking individual cells through extracellular interactions.
CRISPRを用いてノックアウト細胞株を作製する際、ウエスタンブロッティングは細胞株の検証に役立つ有用なツールである。しかし、結果を正しく解釈することは極めて重要である。ここでは、ノックアウト後に起こりうるタンパク質の運命をまとめ、ノックアウト細胞株を検証する最善の方法を探る。
In this blog, we will look at what to do once your gene editing experiment is finished and the different ways you will be able to characterize the successfully modified cell lines.