Trusted reagents for interrogating miRNA function across a wide range of experimental designs
Modulation of microRNA (miRNA) levels is a fundamental approach for understanding miRNA function and the pathways in which they are involved. Dharmacon™ reagents offer both synthetic and lentiviral miRNA mimic, and synthetic inhibitor reagents for every mature human, mouse, and rat miRNA in the miRBase database 21.0. With comprehensive genome-wide coverage and flexible format options, researchers can confidently interrogate any miRNA target from single-gene studies to large-scale functional screens.
miRIDIAN microRNA mimics
Supplement endogenous microRNA activity for functional enhancement studies.
shMIMIC lentiviral microRNA
Expressed lentiviral microRNAs with multiple promoter and reporter options.
shMIMIC inducible lentiviral microRNA
Trusted shMIMIC platform combined with latest generation of powerful Tet-inducible technology.
miRIDIAN microRNA hairpin inhibitors
Suppress miRNA activity to study loss-of-function effects.
miRIDIAN microRNA Mimic Controls
Validated positive and negative mimic controls for optimizing microRNA experiments.
miRIDIAN miRNA Hairpin Inhibitor Controls
Validated positive and negative controls for optimizing microRNA modulation experiments with reliable, accurate results.
Custom microRNA design
Modify an existing miRNA mimic or inhibitor, target a novel microRNA, or request custom miRNA for specialist applications.
microRNA screening libraries
Explore predesigned microRNA screening libraries for gene family, druggable target, whole genome, or custom collections.
Cherry-pick library tool
Upload your gene list to design and order a custom miRNA screening mini-library.
reagents available for every mature human, mouse, and rat miRNA in the miRBase database 21.0
study endogenous microRNA functional activity with microRNA inhibitors or mimics
ensures correct strand loading into RISC and enhanced potency with minimal toxicity
shMIMIC lentiviral miRNA for exogenously introduced miRNA expression with flexible promoter and reporter options
shMIMIC inducible format featuring Tet-On® 3G technology for inducible, controlled miRNA expression
modify existing reagents, target novel microRNAs, or design a custom miRNA screening library
miRNA mimics are designed to mimic endogenous miRNA activity and are used in functional enhancement experiments.
miRNA inhibitors are designed to suppress endogenous miRNA activity and are used in loss-of-function experiments.
