Consistency in end-to-end workflow validation and routine monitoring with patient-like molecular material

Our reference standards are cell line-derived, which means they maintain genomic complexity whilst mimicking patient material from sample preparation to downstream analysis. Suitable for Next Generation Sequencing, droplet-digital and Real-Time PCR as well as Sanger sequencing, Horizon reference standards are platform-agnostic for easy implementation into any quality control workflow.

NGS and PCR quality controls support:

  • Validation of end-to-end diagnostic workflows
  • Robust routine monitoring
  • Confirmation of limits of detection & minimal residual disease status
  • Reducing false positives and negatives
  • Assay development and manufacture

Oncology focused reference material

  • Over 370 clinically-relevant variants
  • Pan-cancer variants including CNVs, SNVs and gene fusions
  • Cancer-specific controls for prostate and myeloid cancers – with more coming soon!
  • Allele frequencies as low as 0.1%

Key features

  • Cell line-derived material is patient-like with full genomic complexity
  • Available in gDNA, FFPE, cell-free DNA and formalin-compromised DNA formats
  • Developed and manufactured under ISO 13485:2016 and ISO 9001:2015
  • Partnered with global EQA and proficiency testing bodies

If you need a specific set of variants, our simple made-to-order online tool can help you create your own reference standard in 5 simple steps.

For bespoke material, our in-house cell line engineering team can support the design of almost any oncology-focused reference standard. Contact us to discuss your project.