Molecular Reference Standards

Consistency in end-to-end workflow validation and routine monitoring with patient-like molecular material

Our reference standards are cell line-derived, which means they maintain genomic complexity whilst mimicking patient material from sample preparation to downstream analysis. Suitable for Next Generation Sequencing, droplet-digital and Real-Time PCR as well as Sanger sequencing, Horizon reference standards are platform-agnostic for easy implementation into any quality control workflow.

NGS and PCR quality controls support:

• Validation of end-to-end diagnostic workflows
• Robust routine monitoring
• Confirmation of limits of detection & minimal residual disease status
• Reducing false positives and negatives
• Assay development and manufacture

Oncology focused reference material

• Over 370 clinically-relevant variants
• Pan-cancer variants including CNVs, SNVs and gene fusions
• Cancer-specific controls for prostate and myeloid cancers – with more coming soon!
• Allele frequencies as low as 0.1%

Key features

• Cell line-derived material is patient-like with full genomic complexity
• Available in gDNA, FFPE, cell-free DNA and formalin-compromised DNA formats
• Developed and manufactured under ISO 13485:2016 and ISO 9001:2015
• Partnered with global EQA and proficiency testing bodies

If you need a specific set of variants, our simple made-to-order online tool can help you create your own reference standard in 5 simple steps.

For bespoke material, our in-house cell line engineering team can support the design of almost any oncology-focused reference standard. Contact us to discuss your project.