Modulating endogenous miRNA targets with miRIDIAN microRNA mimics and inhibitors
MicroRNAs (miRNAs) have been shown to regulate gene expression through both translational attenuation and messenger RNA (mRNA) degradation.
Customized microRNA reagents for any research application
Easily order your ideal Dharmacon™ miRIDIAN™ microRNA mimic or inhibitor - from sequence to synthesis - with flexibility, scale, and chemical expertise. Whether modifying an existing microRNA mimic or inhibitor, targeting a novel microRNA, or requesting an Accell™ microRNA inhibitor or stabilized mimic for special applications, our team can support your research.
Watch our step-by-step video to learn how to use the custom miRNA ordering tool.
Easily apply our proprietary miRIDIAN mimic modification pattern to your microRNA sequence.
Choose from multiple scales and processing options.
Access a wide variety of 5' and 3' chemical modifications.
Scale up for in vivo and large-scale studies.
Order custom self-delivering Accell inhibitors or stabilized miRNA mimics for your assay.
Apply end modifications to mimics or inhibitors to assist in your assay needs.
Request large-scale production of microRNA reagents.
| Product | Description | Best Application |
|---|---|---|
| Custom miRIDIAN Mimics | Apply proprietary modification pattern to your sequence | Novel targets, alternative species |
| Stabilized Mimics | Add stabilizing modifications for nuclease-rich environments | in vivo, serum-containing conditions |
| Accell™ Inhibitors | MicroRNA inhibitor with Accell modifications for reagent-free delivery | Hard-to-transfect cells, primary cells |
| Custom Hairpin Inhibitors | Tailored inhibitors for specialized knockdown | Non-standard targets, mismatch studies |
Contact Scientific support for information and quoting assistance.
Need help entering your sequence using our oligo shortcode? Try using our Dharmacon Oligo Sequence Converter.
Access our Ordering and calculation tools page for convenient webtools to support everything from designing your own siRNA or CRISPR guide against any organism to analyzing your PCR primers.
Revvity's Dharmacon Reagents team adheres to the guidelines in the United States Framework For Nucleic Acid Synthesis. For more information please see our self-attestation.
MicroRNAs (miRNAs) have been shown to regulate gene expression through both translational attenuation and messenger RNA (mRNA) degradation.
Through their effect in down-regulation of gene transcripts, microRNAs play an important role in a range of biological processes such as development.
MicroRNAs are non-coding RNAs that provide critical translational regulation within the cell.
MicroRNAs (miRNAs) are endogenous non-coding RNAs that modulate gene expression through the RNA interference pathway.
Learn quickly how to maximize the success of your next microRNA experiment and accelerate your studies.
Learn about important considerations for in vivo studies with RNAi
Design and performance implications of miRNA tools in vivo.
The only INDUCIBLE multi-promoter, multi-marker, native microRNA context solution.