Cell panel screening assays are an essential part of the drug discovery toolbox. However, fully resolving the drug response profiles of slow-acting therapeutics remains challenging with conventional short term assay formats. Elucidation of the effects of these drug candidates, and those that target epigenetic pathways, requires much greater optimization of longer-term assay conditions.
Reliable and consistent quality reagents are critical to experimental success and reproducibility. Learn about how Dharmacon RNA and DNA oligonucleotide synthesis delivers that level of quality, and explore troubleshooting tips for investigating unexpected results in your experiments.
The reasoning and research behind our Dharmacon™ CRISPRi platform recently published in The CRISPR Journal.
Knowing the distinction between "synthesis scale" and "yield" is critical when ordering custom oligos. Here we explain the terms, so you can make sure to get the right amount for your needs.
All you need to know if you're thinking about labeling your custom oligos with fluorophores.
On Wednesday October 19, The Medical Device Innovation Consortium (MDIC) announced its partnership with PerkinElmer’s Horizon Discovery to develop and manufacture somatic reference samples (SRSs) to simplify and support the validation of NGS-based cancer diagnostics.
Learn about methods for CRISPR activation and determine the best path for your preferred cell model and experimental parameters.
In this blog, we will look at what to do once your gene editing experiment is finished and the different ways you will be able to characterize the successfully modified cell lines.
The presence of off-targets effects can greatly complicate the interpretation of experimental data. Dharmacon™ ON-TARGETplus™ siRNAs and CRISPRmod CRISPRi system are designed to knock down the target gene with minimal off-target effects and are powerful tools for orthogonal validation strategies resulting in highly specific readouts.
Our new Dharmacon™ ASO ordering tool is an online platform created for immediate price quoting and ordering of antisense oligonucleotides. With this custom DNA synthesis tool, you are able to create ASOs with a variety of chemical modifications at a scale and purity to meet your customized needs.