Gene editing

Understand disease mechanisms at the genomic level

 

Gene editing refers to the process of changing regions of cellular DNA. The most common gene editing techniques involve inactivating a gene’s function (knockout), introducing or correcting a SNP mutation, or adding a reporter tag to an endogenous gene (knock-in). These changes are permanent and heritable, resulting in a newly engineered cell line.
With our Edit-R™ CRISPR-Cas9 reagents, researchers can make targeted, specific edits to any gene in practically any cell type. Additionally, Horizon offers a wide selection of pre-made edited cell lines and expert genome engineering services.

Edit-R™ gene editing reagents

Guaranteed to edit your target gene

Algorithm designed CRISPR guide RNA to maximize functional protein knockout and minimize off-target effects.

Also find numerous Cas9 nuclease options, positive and non-targeting controls, and donor templates for HDR-mediated knock-in applications.

Engineered cell models

Ready-to-go or tailored for individual needs

Find 1000's of validated knockout models, point mutations in cancer-relevant cell models, and "CRISPR-ready" stable Cas9 or dCas9-VPR expressing cell lines.

Or use our online tool to design your own cell line and get an instant quote and timeline for your next cell line engineering project.

CRISPR-Cas9 genome editing overview

App note: CRISPR knockout in iPSCs

Highly specific and efficient gene knockout

See how Edit-R reagents are used to generate functional protein knockouts in human induced pluripotent stem cells.

Gene editing workflow guide

Planning a gene knockout or knock-in? 

This workflow guide will assist you in selecting the best Edit-R genome engineering tools for your application.

Guarantee your CRISPR gene editing

CRISPR screening libraries

Accelerate functional genomic screens with CRISPR libraries

Available custom designed or pre-defined in pooled and arrayed formats.

CRISPR & Cas9 All-in-one vector!

Single-transfection solution for a simplified workflow

Express both Cas9 nuclease and a gene specific guide RNA with your choice of fluorescent reporter or antibiotic resistance for easy selection.

Knock-in your edit 

Create a SNP or knock-in a reporter gene

Design templates for precise genomic insertion using the HDR pathway.

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CRISPR Design Tool

Algorithm guided custom CRISPR guide RNA design.

Design guide RNA for use in over 40 species or with any nuclease.

Edit-R™ guarantee

Peace of mind that your editing experiment will be successful

All predesigned guide RNAs are fully guaranteed to edit the target gene, ensuring the highest likelihood of a successful knockout experiment.