Custom RNA and DNA Oligonucleotides
Synthetic RNA and DNA oligonucleotides made to your requirements
Leveraging over 30 years of proven expertise as a global leader in oligonucleotide design and chemical synthesis, our Dharmacon™ Reagents oligo synthesis services deliver the quality, and flexibility your research demands, no matter how complex your experimental requirements.
We specialize in chemically sophisticated synthesis workflows, offering tailored RNA and DNA solutions with adaptable production methods to meet diverse application needs. Whether you require standard oligos for routine molecular biology, modified sequences for enhanced stability, or highly specialized constructs for advanced genomic research, our team provides reliable, high-purity oligonucleotides designed to accelerate your discoveries.
From gene silencing and CRISPR applications to qPCR, sequencing, and synthetic biology, our custom oligo services support a wide range of life science applications. With rigorous quality control, scalable production options, and expert technical support, we ensure every oligo meets your exact specifications, supporting researchers, biotech innovators, and pharmaceutical developers worldwide to advance their work with confidence.
Custom oligo design & ordering tools
-
Single-strand RNA synthesis
Order ssRNA oligos including those with a winde variety of chemicial modifications and purification options
-
siRNA design and synthesis
Design custom siRNA sequences specific to your target and application and order lightly or heavily chemically modified siRNA.
-
CRISPR guide design and synthesis
Design custom CRISPR guides specific to your target and application and order guides in tubes or plates for your CRISPR system.
-
Single-strand DNA synthesis
Order modified or unmodified DNA oligos that fit your experimental needs.
-
Antisense oligonucleotide synthesis
Order antisense oligos (ASOs) including those with unique chemical modifications like locked nucleic acids (LNAs).
-
MicroRNA synthesis
Modify an existing microRNA mimic, target a novel miRNA or request an Accell inhibitor capable of self-delivery
-
Large scale & specialized oligo production
Details on bulk scale or for more highly customized oligo formats, plating/vialing, or production requirements.
Complete your experiment
-
Oligo modifications
A listing of some of the modifications available for our custom oligonucleotides
-
Nucleic acid screening
Details on Revvity's continued compliance with the United States Framework For Nucleic Acid Synthesis Screening
Featured resources
Carousel items
-
Synthesizing long & chemically modified oligos
Download our poster to learn about our patented 2'-ACE chemistry to synthesize long RNA molecules with virtually any chemical modification. -
Dharmacon™ custom oligo synthesis capabilities
Learn about our Dharmacon™ synthetic custom oligonucleotide capabilities in this fun 1-minute video on YouTube. -
Unique methods for internal incorporation of dyes and fluors
Incorporation of molecular probes within synthetic RNA using the 2'-ACE™-5'-Silyl RNA synthesis platform combined with the Levulinyl protecting group provides excellent yield and superior quality of modified full length RNA.
