Dharmacon Reagents
Infinite possibilities for gene perturbation
Transform your research with solutions trusted by innovators worldwide for decades.
Our comprehensive genetic perturbation reagent catalog spans CRISPR, RNAi, and custom oligonucleotide solutions. From single-gene to genome-scale solutions, Dharmacon reagents provide the broadest range of tools to enable functional genomics, examine drug-gene interactions, model disease variants, and much more.
Proven product innovation and scientific expertise:
- 30+ years of experience in chemical oligonucleotide synthesis
- Early innovator in algorithmically designed RNAi and CRISPR reagents
- Expertise in enhancing oligonucleotide performance through chemical modification of siRNA, CRISPR guides, and custom DNA/RNA oligos
- Diverse technologies to induce, repress, knockout, knock-in and edit genes
Reagents
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RNA interference
Synthetic (siRNA) and lentiviral (shRNA) tools for potent and accurate protein-coding and non-coding gene knockdown. -
CRISPR technologies
Synthetic and lentiviral CRISPR tools for knockout, knock-in, interference and activation, and base editing. -
Engineered cell lines
Expert cell line engineering with 7,500+ ready-to-go lines & custom solutions. Thousands of ready-to-go cell lines and custom solutions. -
Custom oligonucleotide synthesis
Customized CRISPR, siRNA, and fully custom oligo design webtools and chemical synthesis solutions. -
Mammalian cDNA & ORFs
cDNA and ORF clones and clone collections for human, mouse, and rat genes. -
Non-mammalian cDNA & ORFs, KO strains, promoter & RNAi collections
cDNA & ORF clones, KO strains, promoter and RNAi collections for yeast, E. coli, C. elegans, Xenopus, & Zebrafish. -
Libraries
Synthetic arrayed or pooled lentiviral whole genome and gene family CRISPR and RNAi libraries and customized libraries.
Featured resources
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Newest arrivals
Tackle today’s most complex genomic challenges with our latest reagents and cell line products. -
Blog posts
Get expert insights, application tips, and latest research trends. -
On the Horizon Blog articles
Detailed application notes, technical literature, and best practices for experiments. -
30+ years in scientific innovation
Explore the history of scientific contribution by Dharmacon scientists.
