HAP1 double knockout cell lines

Collection of ready-to-go double knockouts in a predictable HAP1 cell line model

The HAP1 double knockout collection provides a unique opportunity to study the loss of two interacting or related genes in a predictable HAP1 cell line model. Built off of existing and validated knock-out cell line models, our experienced team used CRISPR to introduce a second gene mutation, resulting in another knock-out.  

Our catalogue of HAP1 double knockouts cover a wide range of biological processes, including lipid biosynthesis, histone modification, and protein degradation. Use our double knockouts to study compensatory mechanisms, protein complex formation, morphological impacts, and much more. 

Discover our catalog of double knockouts below:

 

Double knockout gene combinations
ACSL4 and ACSL3 NUDT9 and NUDT6 SMCR8 and SMCR8
ADARB1 and ADAR RING1 and RNF2 SNCB and SNCA
ALOX12 and ALOX15 RPS6KA5 and RPS6KA5 SUN1 and SUN1
FAM20B and IDS RPS6KA5 and RPS6KA4 TET2 and TET1
GALK2 and NAGK SHPRH and HLTF UBQLN4 and UBQLN1
GAN and SLC35A1 SIK1 and SIK3 USP25 and USP28
GNPTAB and POMK SLC35B2 and XYLT2 XKR8 and ANO6
HIP1R and HIP1 SLC7A8 and SLC7A5 XPA and APEX1
LARGE and POMK SLC7A8 and SLC7A8 XPA and FANCI
ACAD11 and ACAD10 SMCR8 and C9orf72 XPA and NTHL1