OncoSpan cfDNA
Cell-free DNA in buffer or alternate plasma for use in liquid biopsies
Have confidence in your cancer assay
Optimize your validation or monitor assay performance with OncoSpan
Take advantage of a renewable, reproducible, and highly characterized reference control material providing consistency from assay development to routine monitoring.
- Highly multiplexed reference control panel containing over 370 variants across 152 oncogenes, including >27 indels
- Cell line derived control material is commutable to patient samples
- Develop, troubleshoot and assess bioinformatics performance with a companion high coverage, batch specific in silico NGS data set
- Available as cell-free DNA, FFPE curls, and genomic DNA
- Range of allele frequencies enable rapid determination of LOD in your assay and sensitivities
- Demonstrated repeatability and reproducibility with an R2 correlation coefficient in NGS ranging from 0.95 to 0.97 for all OncoSpan formats
OncoSpan applications
- Enable novel cancer assay development
- Conduct routine monitoring of assay performance and data analysis
Utilize NGS controls to calibrate your assays
- Improve patient selection for clinical trials
- Develop early cancer detection methods
- Assess therapeutic efficacy
Choose your OncoSpan format
OncoSpan FFPE
Cells embedded in FFPE slides for use in extraction and assay control
OncoSpan gDNA
High quality genomic DNA for use in assay control
Latest OncoSpan resources
Application Note - Digging deeper into OncoSpan's NGS data
Here we explore deep sequencing information provided with the OncoSpan product range
How to get the most out of your NGS data with OncoSpan
In this blog article we explore how to investigate false calling and downstream applications
OncoSpan publications
Read these research articles citing the use of OncoSpan reference standards.
- Validation of a pan-cancer targeted next generation sequencing panel in New Zealand | New Zealand Journal of Medical Laboratory Science
- Enabling variant calling in challenging FFPE samples by coupling a novel library preparation chemistry with exome sequencing | Journal of Clinical Oncology
- Moving towards a local testing solution for undetermined thyroid fine-needle aspirates: validation of a novel custom DNA-based NGS panel | Journal of Clinical Pathology
- Performance Analysis of Three Bioinformatic Variant Callers Using a Somatic Reference Standard | Children's Mercy Kansas City