Study gene pathways or mimic disease states via gain-of-function assays. 

CRISPR activation offers transcriptional activation of endogenous genes – up to 10,000x basal expression levels. Or exogenously overexpress genes from nearly any species with our extensive cDNA and ORF collections.

CRISPR activation

Increase endogenous gene expression by up to 50,000x.  Transcriptional up-regulation of endogenous genes within their native context.

Mammalian Gene Collection cDNA reagents

Overexpress your gene of interest. Human, mouse, rat, and bovine cDNAs from the Mammalian Gene Collection.

ORF clones

5' and 3' UTRs removed for rapid protein expression. Choose from Gateway or expression-ready ORF collections.

Non-mammalian cDNAs & ORFs

Chose from multiple model organisms. Overexpress genes from Yeast, C. elegans, E. coli, D. rerio or X. laevis.
Overexpression selection guide

Overexpression selection guide

A quick guide to help determine the best gene expression tools for your particular needs.

CRISPRa, cDNA, or ORF: Which is best for my experiment?

A brief comparison of gene expression technologies to help you choose the best for your application.

CRISPRa for potent transcriptional activation

Poster demonstrating an effective strategy to conduct CRISPRa experiments using synthetic crRNA reagents.

cDNA libraries

Genome-scale and gene family MGC cDNA libraries for human, mouse, and rat.

ORF libraries

Predefined gene family collections and customizable cherry-pick ORF libraries.