On the Horizon

Leading news, knowledge, and industry trends in genetic research


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Functional genomic screening allows for the elucidation of the mechanism of action of exogenous agents which modulate intracellular gene function such as pharmaceutical agents and other compounds. Read about the various considerations, approaches and interpretations when conducting a screen to investigate novel compounds and analyzing the screening data.

Large-scale gain-of-function screens have not yet shown the same popularity as loss-of function experiments, mainly due to logistical complications of using the traditional reagents (ORFs). Here we explain the hurdles to setting up a high-throughput ORF screen, and how CRISPRa offers a new solution that can expand the screening toolbox to maximize your window of discovery.

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