Lymphoid Cancer Panel FFPE
リンパ腫には遺伝的変異（体細胞変異）が内在するため、正確な診断と予後は分子および遺伝子プロファイリングに大きく依存します。DLBCLのSOCS1/CDKN2Aや濾胞性リンパ腫のEZH2のような特異的変異は、診断やリスク評価に役立ちます。このような精密検査をサポートするため、私たちが開発したがん細胞株は患者試料を模倣し、FFPEフォーマットで検出可能な臨床的に関連する変異を持つ堅牢な精度管理パネルです。このISO 13485認証パネルは、リンパ腫の管理向上のための正確なコンパニオン診断薬の開発を支援します。
Technical Product Information
Format: FFPE
Fixation method: 4% PFA (w/v)
Section size: 15µm
Cell density: 3 x 108 cells per block. Approx. 3.5 x 105 cells per section
Expected DNA yield: > 400 ng using Promega Maxwell RSC Plus Extraction kit
Genes covered: BRAF, CXCR4, DNMT3A, EZH2, IDH2, MYD88, NRAS, STAT3, TET2, TP53
Allelic frequencies: 6.00 - 14.00%
Verified mutations:
| Gene | DNA sequence change | Amino acid change | Expected frequency (%) |
|---|---|---|---|
| BRAF | c.1799T>A | p. V600E | 10.00 |
| CXCR4 | c.1012C>T | p.R338* | 8.00 |
| DNMT3A | c.2644C>T | p. R882C | 10.00 |
| EZH2 | c.1937A>G | p. Y646C | 10.00 |
| IDH2 | c.514A>G | p. R172G | 10.00 |
| MYD88 | c.794T>C | p. L265P | 10.00 |
| STAT3 | c.1981G>T | p. D661Y | 6.00 |
| TET2 | c.679del | p. E227fs | 9.00 |
| NRAS | c.181C>A | p. Q61K | 10.00 |
| TP53 | c.586C>T | p. R196* | 14.00 |
General information
Storage: 4°C
Shipping: Ambient
Expiration: See all product shelf life information
Intended use: For assay developers, molecular diagnostic labs (Research use only)
Quality control
Allelic frequency: Droplet Digital™ PCR
Quantification: Quantifluor
DNA Integrity: Agarose gel electrophoresis
Manufacturing Quality: ISO 9001:2015 and ISO 13485:2016
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