Cell Lines For Studying Rab GTPases
Rab proteins are key in regulating all aspects of membrane trafficking including vesicle formation, movement along actin and tubulin and fusion with membranes.
These processes makeup the route by which cell surface receptors are trafficked to the cell surface and recycled and cargo is moved between a variety of organelles.
Specific Rabs are physically associated with each organelle as well as their associated transport vesicles. Similar to other GTPases, Rab proteins exist in two conformations; the inactive GDP bound form and the active GTP bound form.
The switch between the two forms is regulated by GTPase activating proteins (GAPs) and GDP/GTP exchange factors (GEFs). Rab dysfunction is implicated in a number of disease states from infectious diseases to cancer.
Examples of popular knockout cell lines for studying Rab GTPases
Human knockout HAP-1 cells
The single largest bank of isogenic cell lines with over 7,500 cell lines to choose from and trusted by academia, biotech, and pharma research labs.
Cancer-related cell lines
Choose from over 300 knock-in and knockout cell line models in many standard cancer cell lines such as DLD1, MCF10A, and HCT116.
Cas9 Stable Cell Lines
Simplify gene editing experiments with stably expressing Cas9 cell lines
CRISPRmod CRISPRa dCas9-VPR Stable Cell Lines
Streamline CRISPR activation experiments with stably expressing dCas9-VPR cell lines
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Top peer reviewed scientific articles using HAP1 cell lines
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