A number of proteins that use bromodomain (BRDs) for their recruitment to specific regulatory complexes have been implicated in the development of cancer. Alongside this, gene re-arrangements and overexpression of BRD containing genes have also been reported in a number of cancers.
BRDs are also attractive targets for neurological and inflammatory diseases - potent and selective inhibitors to the BET (bromodomain and extraterminal domain) family are being trialed.
The human genome encodes 42 bromodomain-containing genes, which harbor 52 bromodomains (some genes contain more than one bromodomain).
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