A number of proteins that use bromodomain (BRDs) for their recruitment to specific regulatory complexes have been implicated in the development of cancer. Alongside this, gene re-arrangements and overexpression of BRD containing genes have also been reported in a number of cancers.
BRDs are also attractive targets for neurological and inflammatory diseases - potent and selective inhibitors to the BET (bromodomain and extraterminal domain) family are being trialed.
The human genome encodes 42 bromodomain-containing genes, which harbor 52 bromodomains (some genes contain more than one bromodomain).
Examples of popular knockout cell lines for bromodomain
|
ASh2L |
BRD4 |
EP300 |
TAF1L |
|
ATAD2 |
BRD7 |
KAT2A |
TRIM24 |
|
ATAD2B |
BRD8 |
KAT2B |
TRIM66 |
|
BAZ1A |
BRD9 |
KMT2A |
ZMYND11 |
|
BAZ1B |
BRDT |
PHIP |
ZMYND8 |
|
BAZ2A |
BRPF3 |
SMARCA2 |
|
|
BPTF |
BRWD1 |
SP100 |
|
|
BRD1 |
BRWD3 |
SP110 |
|
|
BRD2 |
CECR2 |
SP140 |
|
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