As demonstrated by the 2016 Nobel Prize winner, Yoshinori Ohsumi, autophagy is a fundamental process vital to cellular health. The molecular processes and signalling pathways controlling autophagy include numerous autophagy-related (Atg) genes, important stress-inducible intracellular protein, such as p62/A170/SQSTM1 and autophagosome localizing proteins such as LC3, among many others making this a complex network of control
Gene deletion experiments in both mice and cell lines have implicated autophagy in the development of a number of diseases including; neurodegenerative diseases, cancer, infectious diseases, and metabolic diseases.
Furthermore, SNPs and mutations in genes encoding proteins involved in autophagy have been implicated in a wide variety of conditions including asthma, Crohn’s disease and cancers.
Popular knockout cell lines for autophagy pathway
| ATG5 | ATG13 | ATG16L1 |
| SQSTM1 | ATG7 | ATG14 |
| RB1CC1 | ULK1 | ATG12 |
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Human knockout HAP-1 cells
The single largest bank of isogenic cell lines with over 7,500 cell lines to choose from and trusted by academia, biotech, and pharma research labs.
Cancer-related cell lines
Choose from over 300 knock-in and knockout cell line models in many standard cancer cell lines such as DLD1, MCF10A, and HCT116.
Cas9 Stable Cell Lines
Simplify gene editing experiments with stably expressing Cas9 cell lines
CRISPRmod CRISPRa dCas9-VPR Stable Cell Lines
Streamline CRISPR activation experiments with stably expressing dCas9-VPR cell lines