T-cell receptors (TCRs) are crucial components of T cell immunity, enabling the detection and subsequent elimination of abnormal, cancerous and infected cells. Dysfunctional T cell receptor signaling can lead to various immune deficiency or autoimmune diseases. In cancer treatment the study and modification of T cell receptor signaling is important for CAR-T cell therapy as well as modulation of the tumor microenvironment (TME). Modulating T cell activation can be important to avoid rejection of organ or stem cell transplants by the immune response.
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Revvity molecular reference standards are available for both germline and somatic variants. In this article we cover why this distinction is important, and what it means for the allele frequencies of variants in these two types of controls.
On Wednesday October 19, The Medical Device Innovation Consortium (MDIC) announced its partnership with Horizon Discovery to develop and manufacture somatic reference samples (SRSs) to simplify and support the validation of NGS-based cancer diagnostics.
In this blog, we take a look at ClaretBio’s app note on using Horizon’s cfDNA reference standards in the development of their novel sample prep kit.
Learn how to examine your NGS data to investigate false positives and negatives, and potential downstream applications
Horizonの汎用される標準サンプルの全エクソームシーケンスデータがご利用可能となりました。この新しい製品情報が、遺伝子診断法の開発をどのようにサポートできるかについて説明しています。
Horizonの新しい合成マトリックスCell Free DNA標準サンプルは、汎用されるcfDNA抽出キットとの高い適合性があります。
リキッドバイオプシーは、がん患者の腫瘍組織による検査に比べて多くの利点があります。外科的生検をすることなく低侵襲で患者の負担を減らすことができ、検出感度の向上により低頻度の体細胞原因遺伝子変異を検出できるようになってきています。
Quality control (QC) is vital for Next-generation sequencing (NGS). Here we discuss best practices that will save you time, money, and headaches.
Isolation of genomic DNA from formalin fixed paraffin embedded (FFPE) tissues is a critical step for molecular diagnostic (MDx) assays. Here we investigate extraction of DNA from FFPE using five comparable methods.