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ON-TARGETplus Non-targeting Control siRNAs

Negative control siRNAs designed and microarray tested for minimal targeting of human, mouse, or rat genes. ON-TARGETplus modifications reduce potential off-targets. Recommended for determination of baseline cellular responses in RNAi experiments.
dharmacon reagents

ON-TARGETplus Non-targeting Control siRNAs are the ideal negative control for RNAi experiments in human, mouse, and rat cells. ON-TARGETplus Non-targeting siRNAs were designed to leverage seed-region optimization and patented ON-TARGETplus modification patterns to have fewer off-targets than traditionally designed, unmodified negative control siRNAs. Changes in mRNA or protein levels in cells treated with these controls reflect a baseline cellular response that can be compared to the levels in cells treated with target-specific siRNA.

Highlights
  • Ideal negative control for RNAi experiments in human, mouse, and rat cells
  • Chemically matched for use with ON-TARGETplus siRNA reagents
  • Screened by genomewide microarray analysis to verify minimal off-targets