Screening Libraries and Collections
CRISPR and RNAi screening libraries, custom libraries, plus cDNA/ORF and other curated clone collections
For over 20 years, Dharmacon™ CRISPR and RNAi libraries have been the trusted choice for arrayed and pooled gene perturbation and functional genomic screening applications worldwide. Our proven platforms empower researchers to systematically interrogate gene function, identify therapeutic targets, and uncover novel biological pathways with confidence and precision.
Explore our extensive portfolio of pre-designed gene family libraries, drug target collections, and genome-wide screening libraries or work with our team to create custom libraries tailored to your specific target lists. In addition to CRISPR and RNAi solutions, we offer mammalian and non-mammalian collections of cDNA, ORF, and other clone resources, supporting diverse research needs across species and experimental designs.
Whether you're conducting high-throughput screens, validating hits, or building custom assays, our libraries deliver the quality, coverage, and flexibility required for cutting-edge functional genomics research.
Screening libraries plus cDNA/ORF and other clone collections
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CRISPR screening libraries
CRISPR knock-out, activation, and interference libraries. Available as arrayed synthetic and pooled lentiviral formats. -
RNAi screening libraries
siRNA, shRNA, and microRNA libraries. Available in arrayed format. -
Mammalian Gene Overexpression cDNA/ORF Libraries
cDNA/ORF and other clone collections sourced from academic research groups including the Broad, Dana Farber, and others. -
Non-Mammalian Research Libraries
Non-mammalian cDNA & ORF clones, and other genetic strains including knockouts, drug resistance, barcode or reporter fusions, and more. -
Custom libraries
Support for custom target lists with the Cherry-pick custom arrayed library builder and custom pooled lentiviral tool.
FSG screening applications
Systematic gene perturbation at scale is one of the most powerful ways to uncover gene function, map biological pathways, and identify drug targets across the genome. Explore the key considerations for designing and executing high-throughput functional genomics screens, including how to choose between siRNA, shRNA, microRNA, and CRISPR-Cas9 guide RNA libraries for your specific research goals.
