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What is TMB? How is it calculated for our reference standards?
TMB score stands for Tumor Mutational Burden. It is a quantitative measure of how many mutations (genetic changes) exist within a tumor’s DNA.
TMB score is calculated for Whole Exome Sequencing (WES) samples using Illumina DRAGEN in Tumor-Only or Tumor-Normal Mode. For more information regarding the methodology, please refer to the Illumina DRAGEN documentation.
Last updated: Apr 09, 2026