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Xenopus

Fully-sequenced Xenopus Gene Collection (XGC) and IMAGE cDNA clones contain full coding sequences of expressed genes from Xenopus laevis and Xenopus tropicalis.

dio3 ( Western Clawed Frog )

deiodinase, iodothyronine, type 3

Alias

5DIII | DI-3 | dioiii | txdi3
entrezgene 100038242 entrezgene 100038242

The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. As in other verterbrates, studies in xenopus show that this enzyme is involved in early embryonic development. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jun 2016].