Supporting strategies for successful screening. Find the right predefined gene family for your discovery efforts, including gene families, druggable targets, or whole genome. Libraries available as siRNA SMARTpools or set of four individual siRNAs for both ON-TARGETplus 2.0 and Accell 2.0 siRNA products.
CLICK HERE for ON-TARGETplus 2.0™ siRNA and and Accell™ 2.0 siRNA Screening Libraries
With Dharmacon™ ON-TARGETplus™ 2.0 and Accell 2.0 siRNA, your gene-silencing reagents stay relevant to the most current transcriptome data. Our incremental realignment process ensures siRNA designs reflect the latest annotations and delivers consistent gene knockdown that is on-target while minimizing unintended off-target silencing. Combined with our unique siRNA SMARTpool and set of four siRNA formats this fully modernized set of siRNA collections unlocks a new level of confidence using siRNA for gene silencing in modern discovery workflows.
Accell 2.0 libraries extend these capabilities to primary cells and other difficult-to-transfect models through optimized self-delivering chemistry for transfection-free gene silencing.
If you have a gene list of your own not reflected in these predefined collections please use our Cherry-pick custom arrayed plating tool to create your own unique screening library.
See the table below for the various siRNA Screening Libraries offered:
| ON-TARGETplus 2.0 | Accell 2.0 | |
|---|---|---|
| Whole Genome | ✔ | |
| Druggable Genome | ✔ | |
| GPCRs | ✔ | ✔ |
| Ion Channels | ✔ | ✔ |
| Phosphatases | ✔ | ✔ |
| Proteases | ✔ | ✔ |
| Protein Kinases | ✔ | ✔ |
| Ubiquitin Enzymes | ✔ | ✔ |
| Transcription Factors | ✔ | ✔ |
| Drug Targets | ✔ | ✔ |
| Ubiquitin Conjugation Subset 1 | ✔ | ✔ |
| Ubiquitin Conjugation Subset 2 |
✔ | ✔ |
| Ubiquitin Conjugation Subset 3 | ✔ | ✔ |
| Apoptosis | ✔ | ✔ |
| Cell Cycle Regulation | ✔ | ✔ |
| Cytokine Receptors | ✔ | ✔ |
| Deubiquitinating Enzymes | ✔ | ✔ |
| DNA Damage Response | ✔ | ✔ |
| Epigenetics | ✔ | ✔ |
| Membrane Trafficking |
✔ | ✔ |
| Nuclear Receptors | ✔ | ✔ |
| Tyrosine Kinases | ✔ | ✔ |
Please note, the whole genome library contains the Druggable Genome collection which contains 8 discrete sub-collections (light blue), and all remaining protein coding genes annotated in the relevant reference genome.