Mouse ON-TARGETplus siRNA Library Ubiquitin Conjugation Subset 2
siRNA designed and modified for greater specificity
An arrayed collection of siRNA reagents for RNAi screening, targeting mouse F-box and SOCS box E3 ubiquitin ligases. ON-TARGETplus siRNA is guaranteed to silence and is modified to reduce off-targets for fewer false positives.
The Mouse ON-TARGETplus Ubiquitin Conjugation 2 siRNA Library contains F-box and SOCS box E3 ubiquitin ligases, and known and predicted substrate recognition elements for Cul-1 and Cul-2 containing ubiquitin ligases. Well-known members of this E3 ligase family include bTRCP, SKP2, and VHL.
The ON-TARGETplus siRNA designs and modifications reduce off-target effects while maintaining high-silencing potency for high-confidence screening results.
Highlights
- Patented dual-strand ON-TARGETplus modification pattern on all siRNAs to reduce off-targets
- Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake
- Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity
- Available as SMARTpool siRNA reagents or a Set of 4 siRNAs in 96-well plates
- Guaranteed target gene knockdown
Gene Targets
For a complete list of target genes in this siRNA Library, please contact Scientific Support.
For a thorough investigation of the ubiquitin pathway, you may also consider these additional libraries:
