Supporting broader strategies for successful screening, ON-TARGETplus 2.0 libraries help you identify the right predefined gene families for your discovery programs—from druggable targets to whole-genome coverage. Built with next-generation ON-TARGETplus 2.0 design features to maximize specificity and coverage of a genes transcript isoforms, these libraries deliver improved specificity, reduced off-target effects, and robust performance across screening environments.
Available in pooled or individual siRNA formats, ON-TARGETplus 2.0 libraries provide flexible options for high-throughput screens and focused gene sets alike, ensuring reliable gene silencing results for modern discovery workflows.
If you have a gene list of your own not reflected in these predefined collections, submit a quote request for a custom siRNA library.
| ON-TARGETplus 2.0 | ON-TARGETplus | Accell | |
|---|---|---|---|
| Apoptosis | GU2-103900-XX | ||
| Cell Cycle Regulation | GU2-103200-XX | View Details | |
| Cytokine Receptors | GU2-104000-XX | View Details | |
| Deubiquitinating Enzymes | GU2-104700-XX | View Details | View Details |
| DNA Damage Response | GU2-106000-XX | View Details | View Details |
| Drug Targets | GU2-104650-XX | View Details | |
| Druggable Genome | GU2-104600-XX | View Details | |
| Epigenetics | GU2-106100-XX | View Details | View Details |
| G Protein-Coupled Receptors (GPCR) | GU2-103600-XX | View Details | View Details |
| Ion Channels | GU2-103800-XX | View Details | View Details |
| Membrane Trafficking | GU2-105500-XX | View Details | |
| Nuclear Receptor | GU2-103400-XX | View Details | |
| Phosphatases | GU2-103700-XX | View Details | View Details |
| Proteases | GU2-105100-XX | View Details | View Details |
| Protein Kinases | GU2-103500-XX | View Details | View Details |
| Remainder of Genome | GU2-105600-XX | ||
| Transcription Factors | GU2-105800-XX | View Details | View Details |
| Tyrosine Kinases | GU2-103100-XX | View Details | View Details |
| Ubiquitin Conjugation Subset 1 | GU2-105610-XX | View Details | |
| Ubiquitin Conjugation Subset 2 | GU2-105620-XX | View Details | |
| Ubiquitin Conjugation Subset 3 | GU2-105630-XX | View Details | |
| Ubiquitin Enzymes | GU2-105200-XX | View Details | View Details |
| Whole Genome | GU2-105000-XX | View Details | |
Which siRNA is right for you?
Horizon offers multiple predesigned product lines across human, mouse and rat genomes. Use the table below to determine the optimal siRNA for your needs.
| Feature / Attribute | ON-TARGETplus 2.0 siRNA | ON-TARGETplus siRNA | Accell siRNA | siGENOME siRNA | Lincode siRNA |
|---|---|---|---|---|---|
| Key Benefit | Next-generation specificity with minimized off-target effects and improved consistency | High specificity for reduced off-targets + efficient silencing | Target silencing in difficult-to-transfect cells | Cost-effective, efficient silencing | Highly specific knockdown of long noncoding RNA (lncRNA) |
| Gene Coverage | Predesigned for Human, Mouse, and Rat protein-coding genes | Predesigned for Human, Mouse, and Rat protein-coding genes | Predesigned for Human, Mouse, and Rat protein-coding genes | Predesigned for Human, Mouse, and Rat protein-coding genes | Predesigned for Human and Mouse lncRNA |
| Best Use Case | Recommended for high-specificity screening, functional genomics, and follow-up validation | Recommended for transfectable mammalian cells | Recommended for neuronal, suspension, primary, and other hard-to-transfect cells | Recommended for transfectable mammalian cells | Highly specific lncRNA targeting |
| Transfection Requirements | DharmaFECT reagent recommended | DharmaFECT reagent recommended | None required | DharmaFECT reagent recommended | DharmaFECT reagent recommended |
| Available as SMARTpool | |||||
| Available as 4 individual siRNAs | |||||
| Guaranteed Knockdown (SMARTpool + 3 of 4) | (updated design enhances reliability) |
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| Sense Strand Modifications | Selective application as needed | ||||
| Antisense Seed Region Modification | |||||
| Uptake-Enhancing Modifications | Modifications to support delivery | ||||
| Nuclease Resistance | Stabilizing modifications included | ||||
| Sequence Information Provided | |||||
| Product Search | Search ON-TARGETplus 2.0 | Search ON-TARGETplus | Search Accell | Search siGENOME | Search Lincode |