Human ON-TARGETplus siRNA Library - Proteases
siRNA designed and modified for greater specificity
An arrayed collection of siRNA reagents for RNAi screening, targeting human protease genes. ON-TARGETplus siRNA is guaranteed to silence, and is modified to reduce off-targets for fewer false positives.
With the Human ON-TARGETplus Proteases siRNA library, researchers receive siRNAs targeting enzymes with known or predicted protease activity. Proteases, also known as peptidases or proteinases, constitute the largest class of enzymes. Their role is to hydrolyze protein peptide bonds, and through this mechanism, they mediate a great number of physiological processes including embryonic development, wound healing, the immune response, coagulation, apoptosis, digestion, hormonal control, and many others.
Highlights
- Patented dual-strand ON-TARGETplus modification pattern on all siRNAs to reduce off-targets
- Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake
- Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity
- Available as SMARTpool siRNA reagents or a Set of 4 siRNAs in 96-well plates
- Guaranteed target gene knockdown (see Specifications tab)
Gene targets
For a complete list of target genes in this siRNA Library, please contact Scientific Support or your local Sales Representative.
