A review of two studies demonstrating that large-scale pooled base editor screens can separate pathogenic from benign mutations and identify variants that are associated with altered cellular growth or response to DNA-damaging agents.
77 result(s)
The promise of base editing showcases the ingenuity of scientists in their inexorable quest to precisely and safely engineer the genome.
CRISPRaシステムを使用した転写活性化のための化学合成crRNAの有用性を示したThe Journal of Biotechniques掲載（2020年）論文の要約をご紹介します。
Can base editing move cancer cell therapy further towards off-the-shelf treatments?
Gisela Jimenez-Duranらによる最近の論文は、Horizon Discoveryによって実施された全ゲノムCRISPRノックアウトスクリーニングが、炎症誘発性マクロファージを調節できる既存の阻害剤をどのように同定したかをわかりやすく示しています。
CRISPRノックアウトスクリーニング、CRISPRaスクリーニング、またはCRISPRiスクリーニングの実施をお考えですか？化学合成アレイ化ライブラリーまたはプール化レンチウイルスライブラリーのどちらがプロジェクトに最適かどうかご説明しています。
A roundtable discussion with several of the women scientists at Horizon Discovery's Boulder office sharing personal reflections after Jennifer Doudna along with Emmanuelle Charpentier won the Nobel Prize in Chemistry this year.
A summary of a recent publication in The CRISPR Journal showing that Horizon's integrated pooled CRISPRko and high throughput cell panel screening platform together offer clinically relevant information for therapeutic targets.
Here we talk about the role of the Edit-R Pooled sgRNA Indexing PCR Primers and answer the most common questions about the Indexing PCR and Sequencing Primer kit.
Demonstration of a repeatable pooled lentiviral sgRNA screen in primary human T cells