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Master HDR plasmid donor design: homology arm length, gRNA selection, insertion site proximity, and preventing CRISPR re-cutting post-repair
Discover how gene-edited iPSCs create powerful 'disease-in-a-dish' models, and how Revvity's expert CRO services can accelerate your project.
Design effective HDR donor oligos: optimize homology arm length, crRNA efficiency, insertion site proximity, and prevent post-repair CRISPR re-cutting.
Getting started with CRISPR whole genome screening has never been easier with the NEW Dharmacon All-in-one CRISPR platform.
Design and order a plasmid DNA donor kit for insertion of a fluorescent marker
T-cell receptors (TCRs) are crucial components of T cell immunity, enabling the detection and subsequent elimination of abnormal, cancerous and infected cells. Dysfunctional T cell receptor signaling can lead to various immune deficiency or autoimmune diseases. In cancer treatment the study and modification of T cell receptor signaling is important for CAR-T cell therapy as well as modulation of the tumor microenvironment (TME). Modulating T cell activation can be important to avoid rejection of organ or stem cell transplants by the immune response.
Cancer is often characterized by dysregulation in cellular pathways and the checkpoints which control cell proliferation, growth, differentiation, and apoptosis. Within the genome there are two types of genes which carefully control cell proliferation and cell death, which are often the driving force behind oncogenesis.