Our website has a fresh new "look"

We've updated our site with modern design and easier navigation, but you'll still find the same quality Dharmacon™ reagents and Mimix™ reference standards that you love.

We hope you are enjoying the modern design and navigation of our website. Have suggestions for us? Share feedback here.

siGENOME RISC-Free Control

An effective RNAi transfection control that will not be taken up by RISC. Provides a reliable baseline for cellular response to lipid-RNA complexes.
Dharmacon

siGENOME RISC-Free Control is chemically modified to impair processing and uptake by RISC, allowing researchers to isolate cellular effects related to siRNA transfection. As lipid transfection reagents typically rely on charged interaction with the nucleic acid payload, transfection controls using siGENOME RISC-Free are recommended over the use of transfection reagent alone for a more accurate assessment of baseline cellular response.

Highlights
  • Chemical modifications impair uptake and processing by RISC
  • Useful to isolate cellular effects related only to siRNA transfection