Mouse ON-TARGETplus siRNA Library - Ion Channels
siRNA designed and modified for greater specificity
An arrayed collection of siRNA reagents for RNAi screening, targeting mouse ion channel genes. ON-TARGETplus siRNA is guaranteed to silence and is modified to reduce off-targets for fewer false positives.
The Mouse ON-TARGETplus Ion Channels siRNA library contains siRNA reagents targeting transmembrane proteins having known or predicted ion channel activity. These include both ligand-gated channels, such as the nicotinic acetylcholine receptors and voltage-gated channels, such as those that regulate the passage of potassium, sodium, and calcium during polarization and depolarization of the cell membrane.
The ON-TARGETplus siRNA designs and modifications reduce off-target effects while maintaining high-silencing potency for high-confidence screening results.
Highlights
- Patented dual-strand ON-TARGETplus modification pattern on all siRNAs to reduce off-targets (see Supporting Data tab)
- Sense strand is modified to prevent interaction with RISC and favor antisense strand uptake
- Antisense strand seed region is modified to destabilize off-target activity and enhance target specificity
- Available as SMARTpool siRNA reagents or a Set of 4 siRNAs in 96-well plates
- Guaranteed target gene knockdown
Gene Targets
For a complete list of target genes in this siRNA Library, please contact Scientific Support.
