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Lincode Non-targeting Control siRNAs
Dharmacon reagents | Infinite possibilities for genomic perturbation.
CRISPR, RNAi & Custom oligo synthesis. Genome-scale tools for gene knockout, knock-in, knockdown, activation, and more. 30+ years of proven expertise.
Mimix reference standards
Cell line-derived reference materials. Mimic patient samples. FFPE, cfDNA, gDNA, fcDNA formats. Confidently verify your molecular oncology workflows.
We've updated our site with modern design and easier navigation, but you'll still find the same quality Dharmacon™ reagents and Mimix™ reference standards that you love.
Lincode Non-targeting Control siRNAs are ideal negative controls for RNAi experiments for knockdown of human long, noncoding RNAs (lncRNAs). Each of the four available Lincode Non-targeting siRNAs are designed to leverage seed-region optimization and proprietary dual-strand modification patterns to have fewer off-targets than traditionally designed negative control siRNAs. Changes in cells treated with these controls reflect a baseline cellular response that can be compared to the levels in cells treated with target-specific siRNA.
These controls are identical to the ON-TARGETplus Non-targeting siRNAs 1-4 (Cat# D-001810-01, -02, -03, -04). They are also being sold under the Lincode name for ease of ordering by customers new to RNAi. Either catalog item is suitable for Lincode and ON-TARGETplus siRNA experiments.

Lincode siRNAs are modified with a proprietary dual-strand modification that improves siRNA functionality. Additionally, off-targets are reduced due to:
Expert siRNA design and specificity-enhancing modifications for effective knockdown of human long non-coding RNA
A positive control pool of four siRNAs targeting the GAS5 long noncoding RNA (lncRNA) in human cells. Includes patented dual-strand modifications to minimize off-target effects. Useful for determination of optimal RNAi conditions.