Bromodomain diagram
Bromodomain containing proteins
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A number of proteins that use bromodomain (BRDs) for their recruitment to specific regulatory complexes have been implicated in the development of cancer.  Alongside this, gene re-arrangements and overexpression of BRD containing genes have also been reported in a number of cancers.

BRDs are also attractive targets for neurological and inflammatory diseases - potent and selective inhibitors to the BET (bromodomain and extraterminal domain) family are being trialed.

The human genome encodes 42 bromodomain-containing genes, which harbor 52 bromodomains (some genes contain more than one bromodomain).

 

 Explore our popular knockout cell lines for bromodomain

ATAD2

BRD7

KAT2A

SP140

BAZ1A

BRD9

KAT2B

TAF1L

BAZ1B

BRDT

KMT2A

TRIM24

BAZ2A

BRPF3

PHIP

TRIM66

BPTF

BRWD1

SMARCA2

ZMYND8

BRD1

BRWD3

SP100

 ZMYND11

BRD2

CECR2

SP110