On the Horizon

Leading news, knowledge, and industry trends in genetic research

Gene editing

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After all the hard work of editing your cell line, you want to have confidence in your new research model. So, how do you verify your cell line is what you expect it to be? Could a heterogeneous cell population be obscuring your editing effects? Is observed phenotype being caused by the targeted gene edit, or unintended off-target effects? Here we discus ways to add supporting data to validate your gene-engineering projects.



CRISPRテクノロジーは、遺伝子と分子パスウェイをより明確に調べることを可能にしました。どのように、ノックアウト細胞株を、遺伝子レスキューと疾患変異モデルとともに、または独立した細胞モデルとして使用して、研究を検証し、研究成果を拡張できるかを説明しています。


Cancer fusion genes are hybrid genes that produce abnormal proteins believed to catalyze further cancer growth and increase invasiveness. Here we highlight novel research using CRISPR gene editing to specifically target cancer fusion genes, which could offer many potential therapeutic applications.





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