CRISPRによる全ゲノムスクリーニングを開始しましょう。新しいDharmacon all-in-one CRISPRプラットフォームなら、これまで以上に簡単に実行できます。
87 result(s)
Design and order a plasmid DNA donor kit for insertion of a fluorescent marker
T-cell receptors (TCRs) are crucial components of T cell immunity, enabling the detection and subsequent elimination of abnormal, cancerous and infected cells. Dysfunctional T cell receptor signaling can lead to various immune deficiency or autoimmune diseases. In cancer treatment the study and modification of T cell receptor signaling is important for CAR-T cell therapy as well as modulation of the tumor microenvironment (TME). Modulating T cell activation can be important to avoid rejection of organ or stem cell transplants by the immune response.
Cancer is often characterized by dysregulation in cellular pathways and the checkpoints which control cell proliferation, growth, differentiation, and apoptosis. Within the genome there are two types of genes which carefully control cell proliferation and cell death, which are often the driving force behind oncogenesis.
Revvity’s Dharmacon™ CRISPR portfolio expands with validated CRISPR guide RNAs for complex but critical gene targets, as well as DNA cutting controls for screen normalization in sensitive assays.
mTOR （mechanistic Target of Rapamycin）は環境刺激に応答して細胞増殖を制御するシグナル伝達ネットワークの中心であり、細胞および生体の生理学において不可欠な役割を果たしています。
Atlas of Variant Effects Allianceの目標を達成するために、Wellcome Sanger InstituteはRevvityのHAP1 LIG4(-)細胞株を選択しました。
Read about Celonic's decision to partner with Revvity to leverage the CHOSOURCE™ expression platform for all their antibody and complex molecular development and manufacturing.
大腸がん（CRC）は、大腸または直腸の粘膜から始まる異常な細胞増殖です。
The Toll-like receptors (TLRs) are a family of evolutionarily ancient Patten Recognition Receptors (PRRs) that rapidly detect microbial infection and stimulate the production of pro-inflammatory and antiviral cytokines and chemokines, as well as initiating significant metabolic shifts within the cell. Acting as cellular sentinels for infectious threats, signalling downstream of TLRs sets the stage for successful development of adaptive immunity 1.