How do the Edit-R Lethal crRNA controls work? Why do they cause cell death?

Edit-R Lethal crRNA controls work by targeting up to thousands of locations in the genome at once, causing double-strand breaks which have been shown to result in apoptosis. The observed cell death is Cas9- and guide RNA dependent. Synthetic crRNAs require tracrRNA (U-002005-XX) to interact with Cas9 and function properly.