siRNA customization has never been easier

No pre-designed product to fit your needs? Use our online design tools and extensive synthesis options to create a custom siRNA specific for your application. Numerous combinations of modifications, sizes, and purification options are available for convenient online ordering. Watch a short video on how-to-use the siRNA custom tool to quickly generate an online quote for your custom siRNA.

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  • Preclinical scale and OEM RNA & DNA synthesis

    Preclinical scale/OEM service for synthesis of RNA and DNA at larger quantities

  • Order custom siRNA

    Order both modified or unmodified siRNAs. Patented modification patterns (ON-TARGET, ON-TARGETplus, siSTABLE, or Accell) and additional custom modifications are available.

  • Custom SMARTpool design & synthesis

    To complement our pre-designed siRNA collections and support a broad range of RNAi experiments, our siRNA design experts can provide custom SMARTpool reagents targeting genes outside of our genome wide offerings

  • siDESIGN Center

    Design siRNAs targeting genes in non-standard species, particular splice variants or homologous regions across gene families or species.

siRNA Yield Table

For unmodified siRNA, the following approximate yields can be expected:

  Standard (A4) HPLC purified in vivo in vivo HPLC
nmol mg nmol mg nmol mg nmol mg
0.025 µmol scale 20 0.25 - - - - - -
0.05 µmol scale 40 0.5 20 0.25 25 .3 - -
0.2 µmol scale 150 2 80 1 100 1.3 50 0.65
0.4 µmol scale 300 4 160 2 200 2.6 100 1.3
1.0 µmol scale 750 10 320 4 500 6.6 250 3.3
2.0 µmol scale 1500 20 750 10 1000 13 500 6.6
5.0 µmol scale 3750 50 1875 25 2500 33 1250 16
10.0 µmol scale 7500 100 3750 50 5000 66 2500 33

Expert siRNA design assistance is available

Our capabilities include a range of alternative siRNA designs to empower your RNAi research

If you are working in human, mouse or rat models, we may already have what you need as a pre-designed product: Search for your gene in the Search field found in the upper right corner.

Take advantage of our internal design experts and SMARTpool technology! Order a functionally guaranteed Custom SMARTpool for worry-free customization.

Alternative siRNA designs that we support include:

  • Blunt-ended
  • Asymmetrical
  • Longer duplexes (>23 nt)
  • Mismatched strands
  • Alternative bases or linkages

If you can't find what you need or you require additional specifications not available through online order, please request a quote.

For further assistance, please contact Technical Support.

In addition to fluorescent dyes, we offer a broad portfolio of other chemical modifications that can also be applied to both siRNA and single-strand RNA.

For information on our specialized modification patterns for reducing off-targets, self-delivery and nuclease resistance, view the Proprietary siRNA tab.

sense antisense 

siRNA can be modified at either end, on either strand. Multiple modifications are also available but availability may be dependent upon sequence or other factors. Please contact Technical Support for more information

We offer a wide array of oligonucleotide modifications for your specific custom synthesis applications. Scroll through RNA type and position below for online ordering availability.

NOTE: Not all modifications are available through online ordering tool. For assistance please contact Technical Support.

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Showing modifications available for:
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Standard RNA Bases Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
(A,C,G,U) A,C,G,U $6.50 $8.20 $13.70 $18.00 $27.60
2'-Omethyl RNA Bases Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
2'-OMe RNA Bases (A, C, G, U) mA,mC,mG,mU $6.50 $8.20 $13.70 $18.00 $27.60
Standard DNA Bases Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
2'-Deoxy Bases (A, C, G, T) dA,dC, dG, dT $6.50 $8.20 $13.70 $18.00 $27.60
Base Modifications Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
1-Methyl-guanosine m1G $73.00 $80.00 $90.00 $115.00 $200.00
2,6-Diaminopurine DAP $90.00 $95.00 $105.00 $135.00 $230.00
2-Methyl-adenosine m2A $75.00 $93.00 $105.00 $130.00 $230.00
2-Aminopurine 2AP $75.00 $93.00 $105.00 $130.00 $230.00
4-Thio-uridine 4-S-U $100.00 $130.00 $145.00 $180.00 $320.00
5-Bromo-Uridine U[5Br] $73.00 $80.00 $90.00 $115.00 $200.00
5-Fluoro-cytidine C[5F] $73.00 $80.00 $90.00 $115.00 $200.00
5-Fluoro-uridine U[5F] $73.00 $80.00 $90.00 $115.00 $200.00
5-Iodo-uridine U[5I] $73.00 $80.00 $90.00 $115.00 $200.00
5-Methyl-cytidine 5-M-C $73.00 $80.00 $90.00 $115.00 $200.00
5-Methyl-Deoxycytidine 5-M-dC $73.00 $80.00 $90.00 $115.00 $200.00
5-Methyl-uridine rT $73.00 $80.00 $90.00 $115.00 $200.00
Inosine I $30.00 $32.00 $42.00 $58.00 $100.00
N3-Methyl-uridine 3-M-U $73.00 $80.00 $90.00 $115.00 $200.00
N6,N6-Dimethyl-adenosine DMA $75.00 $93.00 $105.00 $130.00 $230.00
N6-Methyl-adenosine m6A $73.00 $80.00 $90.00 $115.00 $200.00
Pseudouridine ~U $90.00 $95.00 $105.00 $135.00 $230.00
Purine ribonucleoside Pu $73.00 $80.00 $90.00 $115.00 $200.00
Pyrrolo-cytidine pC $90.00 $95.00 $105.00 $135.00 $230.00
Ribavirin RBV $73.00 $80.00 $90.00 $115.00 $200.00
Backbone modifications Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
Phosphorothioate * $8.00 $13.00 $15.00 $20.00 $29.00
Phosphorylation Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
5'-Phosphate 5'-P $45.00 $52.00 $63.00 $78.00 $135.00
2'-Modifications Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
2'-Amino-butyryl-pyrene-uridine 2'-P-U $100.00 $130.00 $145.00 $180.00 $320.00
2'-Amino-cytidine 2'-N-C $75.00 $93.00 $105.00 $130.00 $230.00
2'-Amino-uridine 2'-N-U $73.00 $80.00 $90.00 $115.00 $200.00
2'-Deoxy-uridine dU $30.00 $32.00 $42.00 $58.00 $100.00
2'-Fluoro-adenosine 2'-F-A $58.00 $60.00 $85.00 $87.00 $160.00
2'-Fluoro-cytidine 2'-F-C $40.00 $43.00 $57.00 $65.00 $100.00
2'-Fluoro-guanosine 2'-F-G $58.00 $60.00 $85.00 $87.00 $160.00
2'-Fluoro-uridine 2'-F-U $40.00 $43.00 $57.00 $65.00 $100.00
2'-OMe-inosine mI $73.00 $80.00 $90.00 $115.00 $200.00
Amino Modifiers Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
3'-Amino modifier C12 N12-3' $100.00 $130.00 $145.00 $180.00 $320.00
3'-Amino modifier C6 N6-3' $100.00 $130.00 $145.00 $180.00 $320.00
3'-Amino modifier C3 N3-3' $45.00 $52.00 $63.00 $78.00 $135.00
5'-Amino modifier C12 N12 $75.00 $93.00 $105.00 $130.00 $230.00
5'-Amino modifier C3 N3 $73.00 $80.00 $90.00 $115.00 $200.00
5'-Amino modifier C5 N5 $73.00 $80.00 $90.00 $115.00 $200.00
5'-Amino modifier C6 N6 $73.00 $80.00 $90.00 $115.00 $200.00
5-Aminohexylacrylamino-uridine 5-LC-N-U $100.00 $130.00 $145.00 $180.00 $320.00
Thiol Modifiers Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
3'-Disulfide thiol-modifier S-S-3' $100.00 $130.00 $145.00 $180.00 $320.00
5'-Disulfide thiol-modifier S-S $100.00 $130.00 $145.00 $180.00 $320.00
Spacer Modifiers Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
C18 Spacer 18S $30.00 $32.00 $42.00 $58.00 $100.00
C3 Spacer C3 $30.00 $32.00 $42.00 $58.00 $100.00
C9 Spacer 9S $30.00 $32.00 $42.00 $58.00 $100.00
dSpacer dab $75.00 $93.00 $105.00 $130.00 $230.00
rSpacer rab $75.00 $93.00 $105.00 $130.00 $230.00
Chain Terminators Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
3' Inverted abasic b $45.00 $52.00 $63.00 $78.00 $135.00
3' Inverted deoxy-thymidine idT-3' $45.00 $52.00 $63.00 $78.00 $135.00
3'-Terminal 3'-Deoxy-Guanosine 3'dG $55.00 $80.00 $90.00 $120.00 $180.00
3'-Terminal dideoxy-cytidine ddC $75.00 $93.00 $105.00 $130.00 $230.00
5' Inverted deoxy-thymidine idT $30.00 $32.00 $42.00 $58.00 $100.00
5' Terminal 5'-deoxy-ribo-adenosine 5'dA $30.00 $32.00 $42.00 $58.00 $100.00
5' Terminal 5'-deoxy-ribo-cytidine 5'dC $30.00 $32.00 $42.00 $58.00 $100.00
5' Terminal 5'-deoxy-ribo-guanosine 5'dG $30.00 $32.00 $42.00 $58.00 $100.00
5' Terminal 5'-deoxy-ribo-uridine 5'dU $30.00 $32.00 $42.00 $58.00 $100.00
Labeling Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
3-Biotin 3'-Bi $75.00 $95.00 $105.00 $130.00 $190.00
3'-Cholesterol 3'-Chl $110.00 $145.00 $165.00 $210.00 $365.00
3' TEG-Cholesterol TEG-Chl-3' $110.00 $145.00 $165.00 $210.00 $365.00
3'-Cy3 Cy3-3' $85.00 $105.00 $125.00 $145.00 $270.00
3'-Cy5 Cy5-3' $85.00 $105.00 $125.00 $145.00 $270.00
3'-Cy5.5 Cy5^5-3' $85.00 $105.00 $125.00 $145.00 $270.00
3'-Fluorescein 3'-Fl $75.00 $93.00 $105.00 $130.00 $230.00
3'-Biotin LC 3'-LCBi $110.00 $145.00 $165.00 $210.00 $365.00
3'-Biotin LC LC 3'-2LCBi $110.00 $145.00 $165.00 $210.00 $365.00
3'-Puromycin Pmn $45.00 $52.00 $63.00 $78.00 $135.00
3'-TAMRA 3'-TAM $165.00 $200.00 $240.00 $265.00 $460.00
5'-Biotin Bi $90.00 $95.00 $105.00 $155.00 $270.00
5'-Cholesterol Chl $110.00 $145.00 $165.00 $210.00 $365.00
5' Cholesterol-TEG Chl-TEG $330.00 $435.00 $495.00 $630.00 $1,095.00
5'-Cy3 Cy3 $75.00 $95.00 $115.00 $135.00 $250.00
5'-Cy5 Cy5 $75.00 $95.00 $115.00 $135.00 $250.00
5'-Cy5.5 Cy5^5 $75.00 $95.00 $115.00 $135.00 $250.00
5'-Dabcyl Dabcyl $100.00 $130.00 $145.00 $180.00 $320.00
5'-Fluorescein Fl $90.00 $95.00 $105.00 $135.00 $230.00
5'-Pyrene 5'-Pyr $115.00 $155.00 $190.00 $240.00 $460.00
5'-TAMRA TAM $165.00 $200.00 $240.00 $265.00 $460.00
5'-TET TET $75.00 $93.00 $105.00 $130.00 $230.00
Degenerate Bases Short Code 0.05 µmol 0.2 µmol 0.4 µmol 1.0 µmol 2.0 µmol
Pricing shown is for first degenerate base coupling, subsequent additions at standard base pricing
dN dN $45.00 $52.00 $63.00 $78.00 $135.00
dS dS $45.00 $52.00 $63.00 $78.00 $135.00
dW dW $45.00 $52.00 $63.00 $78.00 $135.00
mN mN $45.00 $52.00 $63.00 $78.00 $135.00
rN rN $45.00 $52.00 $63.00 $78.00 $135.00
rS rS $45.00 $52.00 $63.00 $78.00 $135.00
rW rW $45.00 $52.00 $63.00 $78.00 $135.00

Standard modifications for single-strand RNA can also be applied to siRNA by request. Please contact Technical Support to inquire about additional modifications or options for your siRNA, or request a quote now.