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Primary cell models offer increased biological relevance compared to traditional immortalized cell lines. For this reason, researchers often prefer to use primary cells to study gene function, interrogate molecular pathways, or model a disease. Performing gene manipulation in primary cells allows researchers to:
Horizon offers reliable siRNA and CRISPR based solutions for researchers to perform loss- or gain-of-function experiments in biologically relevant models, including stem cells, immune cells, and neurons.
Functional genomics studies in primary immune cells are providing new opportunities for drug target identification and validation, and accelerating the development of diagnostic tools and therapies across a broad spectrum of diseases.
Horizon is focused on optimizing strategies and research tools for RNAi and CRISPR based gene manipulation and screening in primary T and B cell models.
This poster describes a proof-of concept study of pooled CRISPR knockout screening in primary human T cells.
This poster describes CRISPR-Cas9 cell engineering and screening techniques to better understand T cell biology and to find new therapeutic targets.
In this webinar, Dr Verena Brucklacher-Waldert discusses strategies and applications for CRISPRko and RNAi in primary human T cells.
Performing functional genomics experiments in primary stem cells provides insight into developmental pathways and the genes involved in hereditary and autoimmune diseases.
Horizon offers many resources to support the use of our research tools for RNAi and CRISPR based gene manipulation and screening in primary stem cell models.
Build a custom CRISPR or siRNA library
Design your own primary cell screening library with as few as 20 individual siRNA or CRISPR guide RNA using our Cherry-Pick Library Tool. Simply upload your gene list to get started!
Functional genomic studies in primary neurons provide better understanding of the genetic basis for neurological diseases such as Alzheimer's, Parkinson's, Huntington’s and multiple sclerosis.
Horizon offers the following resources to support the use of our research tools for RNAi and CRISPR based gene manipulation and screening in primary neuron cell models.