Dharmacon™ reagents

Infinite reliability for functional genomics

Understanding functional genomics is critical to advance genetic research and therapeutic discovery. Dharmacon Reagents support researchers on this journey at the DNA, RNA, and protein level with the broadest range of functional genomic tools including industry leading gene modulation and gene editing solutions to help elucidate complex biological networks for functional genomic studies.

Known for almost 30 years as premier providers of synthetic oligonucleotides, Dharmacon Reagents were the first to offer algorithm designed synthetic siRNA for RNAi, and the first to offer guide RNA for CRISPR-Cas9 gene editing applications.

Powered by strong relationships and collaborations, we continue to apply organic chemistry with cell and molecular biology to provide innovative tools. Dharmacon Reagents have you covered with a complete range of genomic solutions from single-gene experiments to whole genome screens facilitating advancements in genetic research and therapeutic discovery.

Custom oligo synthesis

Dharmacon RNA and DNA synthesis  Flexible scale and purity to fit experimental needs and budget

RNA interference

Dharmacon siRNA, shRNA, and ncRNA solutions The most simple yet effective method for target gene knockdown in loss-of-function experiments

CRISPR gene editing

Dharmacon guide RNA, Cas9 nuclease, and knock-in reagents Precisely edit any gene in any cell type at any scale

CRISPR modulation

Dharmacon guide RNA, dCas9-VPR, dCas9-SALL1-SDS3 nuclease and more for CRISPR modulation Tools to promote (CRISPRa) or repress (CRISPRi) target gene transcription, without cutting the DNA.

Screening libraries

Dharmacon libraries offer flexibility and scale to fit your needs

Select from whole genome or gene family catalog CRISPR and RNAi libraries or create a custom library in pooled or arrayed format

30 years of Dharmacon reagent innovation

The first premier providers of synthetic RNA oligonucleotides...learn more about our innovative journey

Your partner in research and discovery

Highest quality products for peace of mind

Our scientific support team is always available to help with choosing the right product and experimental support