Custom oligo synthesis
Flexible scale and purity to fit experimental needs and budget
Understanding functional genomics is critical to advance genetic research and therapeutic discovery. Dharmacon Reagents support researchers on this journey at the DNA, RNA, and protein level with the broadest range of functional genomic tools including industry leading gene modulation and gene editing solutions to help elucidate complex biological networks for functional genomic studies.
Dharmacon Reagents have you covered with a complete range of genomic solutions from single-gene experiments to whole genome screens facilitating advancements in genetic research and therapeutic discovery.
Known for almost 30 years as premier providers of synthetic oligonucleotides, Dharmacon Reagents were the first to offer algorithm designed synthetic siRNA for RNAi, and the first to offer guide RNA for CRISPR-Cas9 gene editing applications. Download our infographic to learn more about our journey of innovation.
Want to learn more? Check out our recent blog articles, read about gene editing and RNAi technologies on our application webpages, or search our knowledge base for recent videos, posters, protocols, web tools, and more.
Ready to get started? Browse our reagents here or contact our scientific support team anytime for experimental planning, support, and troubleshooting.
RNA interference
The most simple yet effective method for target gene knockdown in loss-of-function experiments
cDNA & ORF clones
Premium cDNA & ORF clones for gene overexpression studies
CRISPR gene editing
Precisely edit any gene in any cell type at any scale
CRISPR activation
Up-regulate specific gene function at the transcriptional level, without cutting the DNA
CRISPR interference
Down-regulate specific gene function by blocking transcription, without cutting the DNA
Screening libraries
Select from whole genome or gene family catalog CRISPR and RNAi libraries or create a custom library in pooled or arrayed format
Custom libraries
Use our Cherry-pick library tool to turn your gene list into a custom mini-library of synthetic oligos or lentiviral reagents
Transfection reagents and buffers
Proven DharmaFECT™ transfection reagents, ancillary buffers, and media
RNAi
Gene Editing
CRISPR guide RNA
Algorithm designed for highly accurate and efficient functional gene knockout
Cas9 nucleases
Purified and lentiviral expressed Cas9 nuclease solutions
Knock-in templates
Precision homology-directed repair for desired genomic alteration(s)
CRISPR Modulation
CRISPR activation
Up-regulate endogenous gene expression, without cutting the DNA
CRISPR interference
Repress gene expression, without cutting the DNA
Custom Oligonucleotides
Custom RNA synthesis
Versatile design and ordering tool for single-strand RNA
Custom siRNA
Easily create custom siRNA specific for your application
Antisense oligos
Order (ASOs) between 15-35 nucleotides
Custom DNA
Order custom DNA up to 150 bases
Custom miRNA
Custom miRNA for specialized applications
Predesigned Libraries
CRISPR libraries
High functionality and superior specificity in pooled and arrayed screens
Flexible, convenient, and high-confidence screening results with siRNA, shRNA, and microRNA
Custom Libraries
Cherry-pick library builder - synthetic
Design and order libraries of synthetic reagents
Cherry-pick library builder - clones
Design and order libraries of vector-based reagents
cDNA & ORFs
Mammalian collections
Premium cDNA & ORF clones for mammalian gene overexpression studies
Non-mammalian collections
Find clones for Yeast, E. coli, C. elegans, D. rerio, and Xenopus