COVID-19 impacts us all in unexpected ways - If you're still in the lab or working at home please let us know how we can help - Contact Us

Should I use the ON-TARGETplus modification or the siSTABLE modification for my in vivo studies? Can they be combined?

The siSTABLE modification pattern and the ON-TARGETplus modification pattern cannot both be applied to a single siRNA hence you will need to evaluate whether the increased serum nuclease resistance is of more importance than reduction of off target effects in your in vivo research.