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What is the difference between siGENOME and ON-TARGETplus siRNA?

The Dharmacon siGENOME collection of pre-designed siRNA are the most cited siRNA in the world, and have been trusted for superior silencing since 2002. These siRNAs are, for the most part, unmodified and are a reliable choice for every gene silencing application. The ON-TARGETplus collection takes advantage of a dual-strand modification pattern to decrease off-target effects by up to 90%. Both the siGENOME and the ON-TARGETplus products carry the same functional guarantee - 75% silencing or better by the SMARTpool and at least three of the four individuals. We do encourage new research projects and new customers to begin with the ON-TARGETplus platform to have the advantage of the performance-enhancing modifications. The siGENOME products are available for ongoing experiments and for studies which require the use of unmodified siRNAs.