How do I design a CRISPR screen to viral response to cells (viral attack)?

There are several formats that have been used over the years. The two most common are cell death, which makes the screening similar to drug screens, and then viral proliferation and/or re-infectivity. This second method often involves taking supernatant from the first part of the screen to titer new viral particles or look at the ability of the supernatant to subsequently infect new cells. The types of experiments will reveal different aspects of the biology of the virus lifecycle.