genomics discovery initiative

A collaborative functional genomics screening community

The Genomics Discovery Initiative (GDI; formerly the RNAi Global Initiative) is a global consortium of researchers who utilize Dharmacon RNAi and CRISPR screening libraries for high-throughput functional genomics studies. Membership includes but is not limited to:

  • Annual in-person meetings to facilitate collaborations, share key findings and best practices
  • Opportunities to participate in early-access projects with Dharmacon tools and technologies
  • Private LinkedIn message board access for on-the-spot discussion forums, announcements, and FAQs
  • Prioritized, expert technical support from Ph.D. scientists

To learn more, read below or complete the membership information request form.

History

In 2005, Dharmacon founded the RNAi Global Initiative to bring together ten visionary research institutions and investigators to harness the potential of genome-wide siRNA screens as an important functional genomic tool. For 11 years, this community actively engaged to advance our understanding of RNAi technology and the possibilities of arrayed loss-of-function screening.

The results of this Initiative have been substantial; over 60 member institutes worldwide, multiple shared publications, and hundreds of published whole genome siRNA screens (and counting)!

CRISPR and functional screening

The advent of CRISPR-Cas9 as a functional genomics tool has transformed the primary goals of RNAi Global and its members, from experimental screening set-up and support to incorporation of new technologies into functional genomics studies.

The community will now carry a new name, the Genomics Discovery Initiative.

Testimonials from some of our members

“RNAi Global membership has been a great help to us. Being able to attend these meetings lets us interact with these people who are doing cutting-edge work, so we can get a lot of feedback, and a lot of help in terms of setting up our screens”

“It’s a big family…all of these amazingly gifted researchers from all over the world who are experts in screening, coming together.” Jerolen Naidoo, Council for Scientific and Industrial Research

“One of the nicest parts is being in contact with other groups, worldwide, we learn from their experience…[there is] a feeling of friendship that goes beyond the meetings.” Ghil Jona, Weizmann Institute of Science

“I don’t think I can speak highly enough of the entire Initiative as a whole…It’s like no other vendor relationship I’ve had before. They’re not trying to sell you something, they’re working with you.” Kaylene Simpson, Peter MacCallum Cancer Centre

“Working with RNAi Global has allowed us to develop assays quicker, faster, and better.” Ralph Tripp, University of Georgia

Becoming a member

You will receive an invitation to participate in the Genomics Discovery Initiative with qualifying purchase of a Dharmacon CRISPR or RNAi screening library:

  • Druggable, Genome or large gene set of synthetic siRNA or crRNA arrayed library
  • Druggable, Genome or large gene set of lentiviral shRNA or sgRNA clone arrayed library

Participants are typically made up of primary investigators, bioinformaticists, and core facility directors. Postdoctoral researchers, graduate students, and other staff who are active in setting up and supporting screens are also encouraged to participate.

Membership benefits

  • Invitation to attend annual meetings (held alternatively in US and Europe) which provides a forum to present findings, share and learn about novel screening approaches, and collaborate with like-minded scientists
  • Opportunities for early-access to Dharmacon tools and technologies
  • Potential for collaborations and co-development of novel applications
  • Private discussion board for exchange of ideas, posing questions to the group, and other pertinent announcements
  • Prioritized, expert technical support from Ph.D. scientists who draw a knowledge base of over 10 years of direct interaction and support of the screening community to assist with library handling and storage, transfection optimization, and screening strategies.

To learn more, please complete the membership information request form.

Core screening facilities and investigator laboratories at the following institutes are current members of the Genomics Discovery Initiative.

North America

Albert Einstein College of Medicine

British Columbia Cancer Research Centre

Children's Hospital of Eastern Ontario

Fox Chase Cancer Center

Genentech, Inc.

Harvard Medical School

J David Gladstone Institutes

La Jolla Institute for Allergy & Immunology

McGill University

Mount Sinai School of Medicine

National Human Genome Research Institute

National Institute of Allergy and Infectious Diseases (PSIIM)

Novartis Institutes for BioMedical Research

Salk Institute

St. Jude Children's Research Hospital

Stanford University School of Medicine

University of Arkansas for Medical Sciences

University of California, San Francisco

University of Chicago

University of Georgia

University of Manitoba

University of Michigan

University of Nebraska Medical Center

  • UNMC Eppley Cancer Center

University of North Carolina

University of Texas M.D. Anderson Cancer Center

University of Texas Southwestern Medical Center

University of Toronto

  • The Campbell Family Institute for Breast Cancer Research at Princess Margaret Hospital
  • Samuel Lunenfeld Research Institute at Mount Sinai Hospital

University of Wisconsin

Vanderbilt University

Wayne State University

Yale University

Europe

Astra Zeneca

Beatson Institute for Cancer Research

London Research Institute

Institute of Cancer Research

Centre de Regulacio Genomica, Barcelona

Center for Genomic Science of IIT@SEMM

Center for Neuroscience and Cell Biology (CNC), Portugal

Centro Nacional de Investigaciones Cardiovasculares, Spain

Charite - University of Medicine, Berlin

Francis Crick Institute

German Cancer Research Center (DKFZ)

International Centre for Genetic Engineering & Biotechnology, Trieste

Institute of Genetics and Molecular and Cellular Biology

Institut Gustave Roussy

Leiden University

Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP)

Max Planck Institute for Biology of Ageing (MPI-AGE)

Netherlands Cancer Institute (NKI)

Philipps-University of Marburg

Sanofi

Trinity College, Dublin

University College London

University of Basel

University of Cambridge

  • Cambridge Institute for Medical Research
  • Hutchison/MRC Research Centre

University of Dundee

University of Edinburgh Medical School, Division of Pathway Medicine

University of Leeds

University of Lille

University of Manchester

University of Southern Denmark

University of Utrecht Medical Center

VU University Medical Center

Asia and Australia

Australian National University

Genome Institute of Singapore

Institute of Molecular and Cellular Biology, Singapore

Institut Pasteur Korea (IP-Korea)

International Centre for Genetic Engineering & Biotechnology, New Delhi

Shanghai Institutes for Biological Sciences, China

Monash Institute for Medical Research, Australia

Peter MacCallum Cancer Centre, Australia

University of Queensland, Australia

Africa and Middle East

The Council for Scientific and Industrial Research, South Africa

Weizmann Institute of Science (WIS), Israel

Learn about the E-book Frontiers in RNAi authored by 46 contributing member scientists or download it directly here.

The following is a selection of member publications highlighting whole genome and other large screens.

2017

A special issue of Nature Scientific Data dedicated to Data Sharing in Functional Genomics was edited and contributed to by many Genomics Discovery Initiative members. Individual articles are listed below, or view the entire issue.

Simpson, K. J. & Smith, J. A. Knocking down the obstacles to functional genomics data sharing. Sci. Data 4:170019 doi: 10.1038/sdata.2017.19 (2017)

Williams, S. P. et al. Systematic high-content genome-wide RNAi screens of endothelial cell migration and morphology. Sci. Data 4:170009 doi: 10.1038/sdata.2017.9 (2017)

Sun, J. et al. Genome-wide siRNA screen of genes regulating the LPS-induced TNF-α response in human macrophages. Sci. Data 4:170007 doi: 10.1038/sdata.2017.7 (2017)

Li, N. et al. Genome-wide siRNA screen of genes regulating the LPS-induced NF-κB and TNF-α responses in mouse macrophages. Sci. Data 4:170008 doi: 10.1038/sdata.2017.8 (2017)

Pascual-Vargas, P. et al. RNAi screens for Rho GTPase regulators of cell shape and YAP/TAZ localisation in triple negative breast cancer. Sci. Data 4:170018 doi: 10.1038/sdata.2017.18 (2017).

Orr-Burks, N. L. et al. MicroRNA screening identifies miR-134 as a regulator of poliovirus and enterovirus 71 infection. Sci. Data 4:170023 doi: 10.1038/sdata.2017.23 (2017)

Wu, W. et al.Development of improved vaccine cell lines against rotavirus. Sci. Data 4:170021 doi: 10.1038/sdata.2017.21 (2017).

Pettitt, S. J. et al. Genome-wide barcoded transposon screen for cancer drug sensitivity in haploid mouse embryonic stem cells. Sci. Data 4:170020 doi: 10.1038/sdata.2017.20 (2017).

Hodzic J, et. al. Functional Screening Identifies Human miRNAs that Modulate Adenovirus Propagation in Prostate Cancer Cells.. Human Gene Therapy January 2017, doi:10.1089/hum.2016.143.

2016

Tan J, Martin SE (2016) Validation of Synthetic CRISPR Reagents as a Tool for Arrayed Functional Genomic Screening. PLoS ONE 11(12) PMID: 28030641

Chapuis, J., Flaig, A., Grenier-Boley, B. et al. Genome-wide, high-content siRNA screening identifies the Alzheimer’s genetic risk factor FERMT2 as a major modulator of APP metabolism Acta Neuropathol (2016). PMID: 27933404

Evers, et al. (2016) CRISPR knockout screening outperforms shRNA and CRISPRi in identifying essential genes. Nat Biotechnol. 2016 Jun;34(6):631-3. PMID: 27111720

Dutta B, et al. (2016) An interactive web-based application for Comprehensive Analysis of RNAi-screen Data. Nat Commun. 2016 Feb 23;7:10578. PMID: 26902267

2015

G. Sivan, P. Ormanoglu, et al. Identification of Restriction Factors by Human Genome-Wide RNA Interference Screening of Viral Host Range Mutants Exemplified by Discovery of SAMD9 and WDR6 as Inhibitors of the Vaccinia Virus K1L-C7L- Mutant. mBio. B(4), e01122 (2015). PMID: 26242627

2014

Adams M., et al. (2014) A High-Throughput Assay to Identify Modifiers of Premature Chromosome Condensation. J Biomol Screen, Jan 2014; 19: 176 - 183. PMID 23983231

2013

Brusilovsky M, et al. (2013) Genome-Wide siRNA Screen Reveals a New Cellular Partner of NK Cell Receptor KIR2DL4: Heparan Sulfate Directly Modulates KIR2DL4-Mediated Responses. J. Immunol., Nov 2013; 191: 5256 - 5267. PMID 24127555

Perwitasari O, et al. (2103) Targeting Cell Division Cycle 25 Homolog B To Regulate Influenza Virus Replication. J. Virol., Dec 2013; 87: 13775 - 13784. PMID 24109234

Kumar P, et al. (2013) ScreenSifter: analysis and visualization of RNAi screening data. BMC Bioinformatics. 2013 Oct 3;14:290. doi: 10.1186/1471-2105-14-290. PMID 24088301

Börner K, et al. (2013) Robust RNAi enhancement via human Argonaute-2 overexpression from plasmids, viral vectors and cell lines. Nucleic Acids Res., Nov 2013; 41: e199. PMID 24049077

George AJ, et al. (2013) A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation. J. Cell Sci., Dec 2013; 126: 5377 - 5390. PMID 24046455

Petrocca F, et al. (2013) A genome-wide siRNA screen identifies proteasome addiction as a vulnerability of basal-like triple-negative breast cancer cells. Cancer Cell. 2013 Aug 12;24(2):182-96. PMID 23948298

Dai B, et al. (2013) KEAP1-Dependent Synthetic Lethality Induced by AKT and TXNRD1 Inhibitors in Lung Cancer. Cancer Res., Sep 2013; 73: 5532 - 5543. PMID 23824739

Sharma S, et al. (2013) An siRNA screen for NFAT activation identifies septins as coordinators of store-operated Ca2+ entry. Nature. 2013 Jul 11;499(7457):238-42. PMID 23792561

Zawistowski JS, et al. (2013) MicroRNA 9-3p Targets β1 Integrin To Sensitize Claudin-Low Breast Cancer Cells to MEK Inhibition. Mol. Cell. Biol., Jun 2013; 33: 2260 - 2274. PMID 23530058

Fusco DN, et al. (2013) A genetic screen identifies interferon-α effector genes required to suppress hepatitis C virus replication. Gastroenterology. 2013 Jun;144(7):1438-49, 1449. PMID 23462180

Davis SJ, et al. (2013) Functional Analysis of Genes in Regions Commonly Amplified in High-Grade Serous and Endometrioid Ovarian Cancer. Clin. Cancer Res., Mar 2013; 19: 1411 - 1421. PMID 23362323

Carreras Puigvert J, et al. (2013) Systems biology approach identifies the kinase csnk1a1 as a regulator of the DNA damage response in embryonic stem cells. Sci Signal. 2013 Jan 22;6(259):ra5. PMID 23354688

Caradonna KL, et al. (2013) Host Metabolism Regulates Intracellular Growth of Trypanosoma cruzi. Cell Host Microbe 13(1):108-17. PMID 23332160

Warner N, et al. (2013) A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF-{kappa}B Signaling Pathways. Sci. Signal., Jan 2013; 6: rs3. PMID 23322906

Izrailit J, et al. (2013) High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer. PNAS, Jan 2013; 110: 1714 - 1719. PMID 23319603

Lee MN, et al. (2013) Identification of regulators of the innate immune response to cytosolic DNA and retroviral infection by an integrative approach. Nat Immunol. 2013 Feb;14(2):179-85. PMID 23263557

Apelbaum A, et al. (2013) Type I Interferons Induce Apoptosis by Balancing cFLIP and Caspase-8 Independent of Death Ligands. Mol. Cell. Biol., Feb 2013; 33: 800 - 814. PMID 23230268

Schmidt EE, et al. (2013) GenomeRNAi: a database for cell-based and in vivo RNAi phenotypes, 2013 update. Nucleic Acids Res. 2013 January; 41(D1): D1021–D1026. PMID 23193271

Perwitasari O, et al. (2013) Targeting organic anion transporter 3 with probenecid as a novel anti-influenza a virus strategy. Antimicrob Agents Chemother. 2013 Jan;57(1):475-83. PMID 23129053

Siebring-van Olst E, et al. (2013) Affordable Luciferase Reporter Assay for Cell-Based High-Throughput Screening. J Biomol Screen, Apr 2013; 18: 453 - 461. PMID 23112084

2012

Kozik P, et al. (2012) A human genome-wide screen for regulators of clathrin-coated vesicle formation reveals an unexpected role for the V-ATPase. Nature Cell Biology Vol15: 50–60. PMID 23263279

Chia J, et al. (2012) RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells. Mol Syst Biol. 2012; 8: 629. PMID 23212246

Posthumadeboer J, et al. (2012) Targeting JNK-interacting-protein-1 (JIP1) sensitises osteosarcoma to doxorubicin. Oncotarget. 2012 Oct;3(10):1169-81. PMID 23045411

Demir K and Boutros M. (2012) Cell Perturbation Screens for Target Identification by RNAi. Methods in Molecular Biology Volume 910, 2012, pp 1-13. PMID 22821589

Icardi L, et al. (2012) The Sin3a repressor complex is a master regulator of STAT transcriptional activity. Proc Natl Acad Sci U S A. 2012 July 24; 109(30): 12058–12063. PMID 22783022

Steckel M, et al. (2012) Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies. Cell Res. 2012 August; 22(8): 1227–1245. PMID 22613949

Adamson B, et al. (2012) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol 14(3):318-28. PMID 22344029

Sigoillot FD, et al. (2012) A bioinformatics method identifies prominent off-targeted transcripts in RNAi screens. Nat Methods 9(4):363-6. PMID 22343343

Gewurz BE, et al. (2012) Genome-wide siRNA screen for mediators of NF-κB activation. Proc Natl Acad Sci USA 109(7):2467-72. PMID 22308454

Sheveleva EV, et al. (2012) Imexon induces an oxidative endoplasmic reticulum stress response in pancreatic cancer cells. Mol Cancer Res. 2012 Mar;10(3):392-400. PMID 22275514

Zhao H, et al. (2012) A functional genomic screen reveals novel host genes that mediate interferon-alpha’s effects against hepatitis C virus. J Hepatol 56(2):326-33. PMID 21888876

2011

Cotta-Ramusino C., et al. (2011) A DNA damage response screen identifies RHINO, a 9-1-1 and TopBP1 interacting protein required for ATR signaling. Science 332(6035):1313-7. Pubmed

Metzig M, et al. (2011) An RNAi screen identifies USP2 as a factor required for TNF-a-induced NF-jB signaling. Int. J. Cancer: 129, 607–618. Pubmed

Senapedis WT, et al. (2011) Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Molecular Biology of the Cell 22, 1791-805. Pubmed

Hattori H, et al. (2011) Context dependence of Checkpoint kinase 1 as a therapeutic target for pancreatic cancers deficient in the BRCA2 tumour suppressor. Mol Cancer Ther. 2011 April; 10(4): 670–678. Pubmed

Sigoillot FD and King RW (2011) Vigilance and Validation: Keys to Success in RNAi Screening. ACS Chem Biol 6(1):47-60. Pubmed

Winograd-Katz SE, et al. (2011) Analysis of the signaling pathways regulating Src-dependent remodeling of the actin cytoskeleton. Eur J Cell Biol. 2011 Feb–Mar; 90(2-3): 143–156. Pubmed

Keklikoglou I, et al. (2011) MicroRNA-520/373 family functions as a tumor suppressor in estrogen receptor negative breast cancer by targeting NF-κB and TGF-β signaling pathways. Oncogene. 2011 Dec 12. doi: 10.1038/onc.2011.571. [Epub ahead of print] Pubmed

Jailkhani N, et al. (2011) Delineation of key regulatory elements identifies points of vulnerability in the mitogen-activated signaling network. Genome Res. 2011 Aug 24. [Epub ahead of print] Pubmed

Chong R, et al. (2011) RNAi Screen Reveals Host Cell Kinases Specifically Involved in Listeria monocytogenes Spread from Cell to Cell. PLoS One. 2011;6(8):e23399. Epub 2011 Aug 10. Pubmed

Bai SW, et al. (2011) Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. BMC Biol. 2011 Aug 11;9(1):54. Pubmed

Genovesio A, et al. (2011) Automated Genome-Wide Visual Profiling of Cellular Proteins Involved in HIV Infection. J Biomol Screen. 2011 Aug 12. [Epub ahead of print] PubMed

Zhang JD, et al. (2011) Time-resolved human kinome RNAi screen identifies a network regulating mitotic-events as early regulators of cell proliferation. PLoS One. 2011;6(7):e22176. Epub 2011 Jul 13. Pubmed

Genovesio A, et al. (2011) Visual genome-wide RNAi screening to identify human host factors required for Trypanosoma cruzi infection. PLoS One. 2011;6(5):e19733. Epub 2011 May 20. PubMed

Jiang M, et al. (2011) Tales from an academic RNAi screening facility; FAQs. Brief Funct Genomics. Jul;10(4):227-37. doi: 10.1093/bfgp/elr016. Epub 2011 Apr 28. PubMed

Nijwening JH, et al. (2011) Screening for modulators of cisplatin sensitivity: Unbiased screens reveal common themes. Cell Cycle. Feb 1;10(3): 380-6. Epub 2011 Feb 1. PubMed

2010

Samavarchi-Tehrani P, et al (2010) Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogramming. Cell Stem Cell Jul 2;7(1):64-77. PubMed

Lipinski MM, et al. (2010) A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions. Dev Cell 18, 1041-05220627085. PubMed

Cappell KM, et al. (2010) Symplekin specifies mitotic fidelity by supporting microtubule dynamics. Mol Cell Biol. 2010 Nov;30(21):5135-44. Epub 2010 Sep 7. PubMed

Whitehurst AW, et al. (2010) Tumor antigen acrosin binding protein normalizes mitotic spindle function to promote cancer cell proliferation. Cancer Res. 2010 Oct 1;70(19):7652-61. Epub 2010 Sep 28. PubMed

Juul N, et al. (2010) Assessment of an RNA interference screen-derived mitotic and ceramide pathway metagene as a predictor of response to neoadjuvant paclitaxel for primary triple-negative breast cancer: a retrospective analysis of five clinical trials. Lancet Oncol. 2010 Apr;11(4):358-65. Epub 2010 Feb 26. PubMed

Smith JA, et al. (2010) Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. PNAS 107(8):3752-7. PubMed

Tolopko AN, et al. (2010) Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities. BMC Bioinformatics 11(1): 260. PubMed

Leber B, et al. (2010) Proteins Required for Centrosome Clustering in Cancer Cells. Science Translational Medicine, 2: 33ra38. PubMed

Fuchs, F et al. (2010) Clustering phenotype populations by genome-wide RNAi and multiparametric imaging. Mol Syst Biol. 2010 Jun 8;6:370 PubMed

Santhakumar, D et al. (2010) Combined agonist-antagonist genome-wide functional screening identifies broadly active antiviral microRNAs. Proc Natl Acad Sci U S A. Aug 3;107(31):13830-5 PubMed

Komurov, K et al. (2010) Comprehensive Mapping of the Human Kinome to Epidermal Growth Factor Receptor Signaling. J Biol Chem. Jul 2;285(27):21134-42 PubMed

Burrows, AE et al. (2010) Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence. Proc Natl Acad Sci U S A. Aug 10;107(32):14280-5 PubMed-

Nakada, S et al. (2010) Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature. Aug 19;466(7309):941-6 PubMed

Ahmed AA, et al. (2010) SIK2 is a centrosome kinase required for bipolar mitotic spindle formation that provides a potential target for therapy in ovarian cancer. Cancer Cell. Aug 9;18(2):109-21 PubMed

2009

Jrgensen C, et al (2009) Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cells. Science Dec 11;326:1502-9. PubMed

Miller BW,et al. (2009) Application of an integrated physical and functional screening approach to identify inhibitors of the Wnt pathway. Molecular Systems Biology 5:315. PubMed

Brass, A.L, et al. (2009). The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus. Cell 139:1243-1254. PubMed

Hu, G., et al. (2009) A genome-wide RNAi screen identifies a new transcriptional module required for self-renewal. Genes Dev. 2009 Apr 1:23(7):837-48. PubMed

Li, Q., et al. (2009). A genome genetic screen for host factors required for hepatitis C virus propagation. PNAS 106(38):16410-5. PubMed

Tai, A.W., et al. (2009). A functional genomic screen identifies cellular cofactors of Hepatitis C virus replication. Cell Host Microbe. 2009 Mar 19;5(3):298-307. PubMed

Tsui, M., et al. (2009). An intermittent live cell imaging screen for siRNA enhancers and suppressors of a kinesin-5 inhibitor. PLoS One. 2009 Oct. 5;4(10):e7339. PubMed

Birmingham A, et al. (2009) Statistical methods for analysis of high-throughput RNA interference screens. Nat Methods. Aug;6(8):569-75. PubMed

Stewart GS, et al. (2009) The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage. Cell. 136(3):420-34. PubMed

2008

Lau KS, et al. (2008) Genome-scale identification of UDP-GlcNAc-dependent pathways. Proteomics. 8(16):3294-302. PubMed

Ohn, T. et al. (2008) A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly. Nature Cell Biology 10(10): 1224-1231. PubMed

Brass, A.L. et al. (2008) Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen. Science 319, 921-926. PubMed

Krishnan, M.N. et al. (2008) RNA interference screen for human genes associated with West Nile virus infection. Nature. 455 (7210):242-245.. PubMed

Tang, W. et al. (2008) A genome-wide RNAi screen for Wnt/β-catenin pathway components identifies unexpected roles for TCF transcription factors in cancer. PNAS 105: 9697-9702. PubMed

Simpson K, et al (2008) Identification of genes that regulate epithelial cell migration using an siRNA screening approach. Nature Cell Biology 10(9): 1027-1038. PubMed

2007

Kolas, N. K. et al. (2007) Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase. Science, 318: 1637 - 1640. PubMed

Swanton C, et al. (2007) Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to Paclitaxel and other chemotherapeutic drugs. Cancer Cell. 2007 Jun;11(6):498-512. PubMed

Whitehurst AW, et al. (2007) Synthetic lethal screen identification of chemosensitizer loci in cancer cells. Nature. 2007 Apr 12;446(7137):815-9. PubMed

Learn more about the products that may qualify you for participation in the Genomics Discovery Initiative.

Edit-R crRNA Libraries

  • Plated pre-defined collections of popular human and mouse gene families for arrayed knockout screening.

Edit-R Arrayed Lentiviral sgRNA Libraries

  • Arrayed collections of lentiviral sgRNA libraries for high-throughput knockout screening across entire human gene families.

Human siRNA Libraries

  • Find the predefined gene family, including Druggable genes or Whole Genome, that’s right for your discovery efforts.

Mouse siRNA Libraries

  • A wide selection of predefined siRNA libraries, including the most up-to-date whole Mouse genome collection available.

Cherry-pick Libraries

  • Fast and easy online configuration and ordering of plated RNAi and CRISPR reagents targeting your genes of interest.