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How is 2'-ACE deprotection accomplished?

RNA oligos are incubated at elevated temperatures in the presence of a mildly acidic buffer to remove the 2'-ACE protecting group. The buffer used is dilute (100 mM) acetic acid adjusted to a pH of 3. 8 using TEMED. A deprotection protocol is available on our website for 2'-ACE stabilized RNA oligos.