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Will SMARTvector shRNA sequences target the same gene in human, mouse and rat cell lines?

Due to the polymorphisms that exist among these organisms, SMARTvector Lentiviral shRNA gene silencing constructsdesigned against one organism generally do not target other organisms. For this reason, the SMARTvector algorithm hasbeen employed to pre-design constructs for each gene in the human, mouse and rat genomes.